Vol. 01, Issue 2, July 2014

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Subject: search.filters.subject.Dissolution

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    Performance Evaluation of Different Brands of Chlorpheniramine Maleate (Antihistamine) Tablets Available in Bangladesh
    (Daffodil International University, 2014-07-01) Zaman, KH Ahammad Uz; Sultana, Sharifa; Deepa, Kanij Nahar; Akter, Sathi
    In Bangladesh, at present about 60 pharmaceutical companies are manufacturing 90 brands of Chlorpheniramine Maleate tablets. This project work has been designed to evaluate & report the quality & stability of some marketed Chlorpheniramine Maleate tablets available in Bangladesh. The selected brands were assayed spectrophotometrically and their physical parameters (weight variation, hardness, thickness, friability, disintegration time, and dissolution rate) were analyzed according to the official (BP/ USP) pharmacopial methods to evaluate their quality. The results showed that 7 brands of tablets meet the USP specification of potency and the remaining one brand was highly potent. All but one brands showed good results when they were tested for weight variation, thickness, disintegration time, It is evident from the study that most of the brand tested showed good result but few of them are substandard. So more steps and effective measures should be taken by the authority to ensure quality medicine.
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    Comparative Quality Evaluation of Different Brands of Frusemide Tablets Available in Bangladeshi Market
    (Daffodil International University, 2014-07-01) Sultana, Sharifa; Deepa, Kanij Nahar; Zaman, KH Ahammad Uz; Yesmin, Nafisa
    Frusemide is a widely produced and marketed drug by many Pharmaceutical companies in Bangladesh. The performance evaluation (Namely, some physical parameters, potency, disintegration and dissolution profile), of Frusemide tablets from six different pharmaceutical companies was carried out in order to find out whether they really complied the required standards. As a part of evaluation of physical parameters, the size and shape, specially, thickness of representative samples of each pharmaceutical companies were evaluated and they were found to be uniform. The tablets from all the companies successfully passed the friability test as the % of friability of all of them were found to be way below one. Out of the tablets of six evaluated pharmaceutical companies, the potency of Frusemide tablets from five companies was found to be satisfactory and one was poor. The disintegration time of tablets from all the companies were found to be satisfactory. The minimum disintegration time was found to be 2.50 minute and the maximum disintegration was found to be 5 minutes. The dissolution profile of the representative sample was determined. The profiles for all the companies were satisfactory. The best profile was showed 90.42% at 45 minutes and 92.50% at 50 minutes.