Review on simultaneous estimation of fixed dose combination: system suitability parameter of RP-HPLC analysis
Date
2023-01
Authors
Journal Title
Journal ISSN
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Publisher
BRAC University
Abstract
In modern pharmaceuticals, Reverse Phase- High performance Liquid Chromatography (RP-
HPLC) is one of the most essential tools. When analyzing, attempting to separate, and
identifying compounds from a complicated mixture, RP-HPLC is the most advantageous
option because it permits purification of most classes of compound. For any chromatography
system suitability is required and are designed to assess the analytical system's constituent
parts and demonstrate that its performance satisfies the criteria set forth by the method. 12
articles were picked from number of reliable sources and journals where RP-HPLC was used
to asses combination drugs in solid dosage form. In this review article, the system suitability
of those selected studies is reviewed on the basis of USP guideline in order to criticize and
evaluate the robustness of the method. If any incomplete or misleading information was
identified, the possible cause and solution for those methodologies were explained in this
review.
Description
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 19-20).
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
Includes bibliographical references (pages 19-20).
This thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2023.
Keywords
Reverse Phase- High performance Liquid Chromatography (RP-HPLC), System suitability, Combination drugs