Evaluation of the Quality Control Parameters of Two Different Brands (Losucon and Dieta) of Glimepiride Tablets Available in Bangladesh

Abstract

Evaluation of the quality control parameter is always a better way for the understanding of the quality of local brands. Thus, the purpose of this research work was to determine the physical quality control parameter and the potency of two different brands (Losucon and Dieta) of glimepiride 2mg tablets (Two batches of each) which is used for the treatment of type II diabetes.According to the research study all the tablets showed a percentage weight variation within the range and meet the specification of USP. Thicknesses test of all the tablets of two different brands represents variable results but was also within acceptance range. All the tablets of these two brands had hardness lower than the standard value of 4 kg which can cause breakdown of tablets during use and transport. All the tabletsmeet the specification for disintegration time in accordance to BP. Average percent dissolution of all the batches meet the specification range. But some tablets individually were not dissolved 80% within 30 minutes. Both batches of Losucon meet the specification of potency (103.67% and 108.47%) according to BP and USP where the batches of Dieta had failed. All the test result were confirmed with the calculation of their standard deviation. As the friability study could not be performed due to some technical faults, further research for assuring the quality of drug in the local market should to be conducted.