EFFECTS OF SPIRULINA ON COPPER SULPHATE INDUCED TOXICITIES IN MICE

Abstract

The present study was performed for finding the effect of spirulina in Copper Sulphate induced toxicities in mice. Twenty five healthy mice were randomly divided into five equal groups recognized as TO, T1, T2, T3 and T4 .Group T0 was kept as a control group whereas T1 was only treated with Copper Sulphate @ 20mg per 100ml drinking water. Group T2 was treated with Copper Sulphate @ 20 mg and Spirulina @ 70mg per 100ml drinking water. Group T3 was treated with Copper Sulphate @ 20 mg and Spirulina @ 140mg per 100ml drinking water. Group T4 was treated with copper Sulphate@ 20 mg and Spirulina @ 280 mg per 100ml drinking water. Mice of group To (only Copper Sulphate) showed sudden onset of depression, restlessness, anorexia. The body weight gain was minimum (54.43%) in mice of only Copper sulphate treated T1 group in comparison to control group (T0). On the other hand, other treated group i.e. Copper Sulphate plus spirulina treated groups T2, T3, and T4 the gaining body weight was 35.29%, 33.83% and 8.82% respectively, which was higher than only Copper Sulphate group T1. Reduction of TEC, Hb and PCV values were significant (P<0.01) in T1 (Copper Sulphate treated) groups. However, in copper plus spirulina treated rest group’s reduction of TEC, Hb, and PCV were less than Copper Sulphate treated group. From the study, it can be concluded that the treatment with spirulina was effective in Copper Sulphate induced toxicities and to restore altered values of Hematological Parameters.