ASSESSMENT OF THE EFFECT OF DIFFERENT ANAESTHETICS AND PAIN RESPONSE AFTER LAPAROTOMY IN RABBIT

Abstract

This study was carried out for the assessment of various anaesthetic combinations on pain management after laparotomy and to find out the best combination of premedication and anaesthetic drugs for prevention of pain in rabbits during the period from JulyDecember, 2018 in the Department of Medicine, Surgery and Obstetrics, Faculty of Veterinary and Animal Science, Hajee Mohammed Danesh Science and Technology University, Dinajpur, Bangladesh. Fifteen rabbits were allocated into three equal groups. The treatment groups were the Midazolam-Ketamine-Xylazine (MKX), MidazolamAcepromazine-Ketamine (MAK) and Acepromazine-Diazepam-Fentanyl (ADF). The levels of analgesia and wound tenderness were assessed by dynamic interactive visual analogue scale (DIVAS). Parametric variables were analyzed using one-way ANOVA in the appropriate cases. Overall, postoperative pain and wound tenderness score increased significantly (p<0.01and p<0.05) irrespective of groups. Pain decreased significantly (p<0.01 and p<0.05) in MKX group compared to other two groups. Similarly, wound tenderness decreased significantly (p<0.01) in MKX group at each observation compared to other two groups (MAK and ADF). Midazolam-Ketamine-Xylazine (MKX) combination has significantly (p<0.01) lower induction period, higher duration of anaesthesia and rapid recovery. No adverse event or reaction was observed through the courses of the study. It was demonstrated that Midazolam-Ketamine-Xylazine group provided an excellent analgesia compared to MAK and ADF. A multimodal approach of anaesthesia during laparotomy in rabbits is suggested for prevention of pain.