Evaluation of Quality Control Parameters and In Vitro Dissolution Study of Various Brands of Atenolol Available In Bangladesh

Abstract

This research work is aimed to investigate the quality control parameters of different batches of three brands of atenolol available in the Bangladeshi market. Three batches from each brand were selected. These brands were Tenoloc, Tenoren, and Cardipro. Quality control tests were performed for evaluation of hardness, thickness, weight variation, friability, disintegration time and dissolution of the tablets from each brand. These tests were performed according to the specification of USP and BP. Hardness value and disintegration time among batches were within acceptance region. Weight variation of all batches of Tenoloc, Tenoren and Cardipro fulfilled the specification. But Percent friability of some batches fulfilled the specification and some did not. Dissolution rate of Tenoloc and Cardipro complied with specification, but dissolution rate of Tenoren did not comply with the specification described in BP.