EFFECTS OF SPIRULINA ON POTASSIUM DICHROMATE INDUCED TOXICITIES IN MICE

Abstract

The present study was performed to observe the effect of spirulina in potassium dichromate induced toxicities in mice. Twenty five healthy mice were randomly divided into five equal groups recognized as T0, T1, T2, T3 and T4 .Group T0was kept as a control group whereas T1was only treated with Potassium dichromate 40mg per 100ml drinking water. Group T2 was treated with Potassium dichromate 40mg and spirulina 70mg per 100ml drinking water. Group T3 was treated with Potassium dichromate 40mg and spirulina 140mg per 100ml drinking water. Group T4 was treated with Potassium dichromate 40mg and spirulina 280 mg per 100ml drinking water. Mice of group T0 (only Potassium dichromate) showed sudden onset of depression, restlessness, anorexia. The body weight gain was minimum (36.38%) not gain in mice of only Potassium dichromate treated T1 group in comparison to control group (T0). On the other hand, other treated group i.e Potassium dichromate plus spirulina treated groups T2, T3, and T4 the not gained body weight was 27.58%, 18.25% and 7.79% respectively, which was higher than only Potassium dichromate T1 group. Reduction of TEC, Hb and PCV values were significant (P˂0.01) in T1 (Potassium dichromate treated) groups. However, in potassium dichromate plus spirulina treated rest group’s reduction of TEC, Hb, and PCV were less than Potassium dichromate treated group. From the study, it can be concluded that Potassium dichromate is harmful to the body showing some toxic signs and also alterations some hematological parameters, where as Spirulina was found to be an effective in reduction of body burden of potassium dichromate.