Antidiabetic And Free Radical Scavenging Activities Of Methanolic Extract Of Citrullus Lanatus (Fruit Rind)

Abstract

Free radicals are associated with Diabetes and its complications. The present study was designed to investigate DPPH scavenging in-vitro antioxidant activity and antidiabetic activity on alloxan induced diabetic mice. Mice treated with extract dose at 300mg/kg p.o, showed a remarkable decrease ( ***p<0.001) of blood glucose concentration at 90min and 120min compared to diabetic control group and metformin was taken as a reference standard. In this study antioxidant activity of Citrullus lanatus was g/mlg/ml in contrast with ascorbic acid IC50 was 36.34 IC50 was 102.51 g/ml.g/ml in contrast with ascorbic acid IC50 was 36.34 g/ml.