RELIABLE DIAGNOSTIC TECHNIQUES FOR CANINE DIABETES WITH HISTOPATHOLOGICAL EFFECTS OF ORGANS

Abstract

The study was planned to find out a reliable diagnostic techniques for canine diabetes with histopathological effects on different organs. A total number of 53 candidate diabetic dogs from SAQTVH, CVASU and Chittagong metropolitan area were studied. Diabetes in dogs were determined on the basis of clinical finding, hematological profile and serum biochemical profile evaluation. Organs specimens from a dead diabetic and healthy dog were collected for histopathological studies. The prevalence of diabetic dog was 5.76%. The mean blood glucose parameter in diabetic dog was 11.5±0.42 mmol/L. TLC (10.48±0.32 ×103 /μl), ALT (143.38±2.66 IU/L), cholesterol (237.68±0.43 mg/dl) and glycated haemoglobin (9.51±0.31%) values were significantly elevated in diabetic dogs than that of control dog. Glycated haemoglobin (HbA1c %) test was more reliable than portable blood glucose measurement device test, oral glucose tolerance test and hematological profile evaluation test. Histopathologically, the number and size of pancreatic islet were reduced with degeneration, fatty deposition, fibrosis and necrosis. The villus length of intestinal mucosa was shorter (1.1 mm) in diabetic dog than healthy dog (1.5 mm). Cellular infiltration and fatty deposition were observed in liver of diabetic dog. HbA1c test might be useful to clinician for effective diagnosis of canine diabetes and histopathology of different organs might provide knowledge about deleterious effects on organs.