Masters of Thesis

Browse

Now showing 1 - 20 of 25

A Novel Analytical Method Development of Esomeprazole Pellet
(Daffodil International University, 2024-01-22) Sarker, Md. Shah Newaj
Proton pump inhibitors (PPIs), also called gastric medicine, are among the most frequently prescribed medications globally. Medications such as Esomeprazole, Omeprazole, Pantoprazole, and others have nearly become ubiquitous in Bangladesh. Although available in various forms on the market, capsules (pellets) are the most prevalent. Analyzing pharmaceuticals is laborious because only a limited number of pharmaceutical companies produce them internally; the rest purchase granules that have been filled into capsule shells and sold. Thus, only a few in-house methods exist to facilitate the analytical process. The majority of them rely on pharmacopoeial methods such as BP and USP. Although these techniques are widely used, they may only apply to some pharmaceuticals. Therefore, this study is preoccupied with developing a novel technique to facilitate the analysis of PPI pellets. It is a finished product for a company that has only sold granules; it is a raw material for a purchaser. The analytical technique can, therefore, be identical for both. For an analyst to analyze these PPI granules, an effective method for both the primary material and the final product must exist. This analysis uses High-Performance Liquid Chromatography (HPLC), the most effective method for separating and identifying mixtures of various components. In addition, distinct reagent and chromatographic conditions are implemented, given that this is a novel methodology. The ultimate findings exhibit encouraging results. This approach reduces both time and analysis costs, albeit with minor drawbacks. Esomeprazole, PPI, particle analysis, HPLC, and the development of analytical methods are all keywords
A scientific Research on Synbiotic Impacts of Brown Rice and Beet Root with Yogurt on Hypolipidemic, Hypoglycemic, Hepatoprotective, Gut Health, and CNS-depressant Activities in Exploratory Mice”
(Daffodil International University, 2024-07-05) Emu, Mst. Nasrina Akter
The outline of this research study is how it affects mice when they intake fiber combination with other materials as yogurt, standard statin and standard synbiotic. Cardiovascular ailment, diabetic complications, as well as liver damaging, and uneasiness are the most continual disorder around the world. Conventional medicines can cause bradycardia, shortness of breath, inconvenience in the stomach, and different other liver and kidney emerge. Regardless both of these ongoing difficulties, this most recent vivo study investigation was carried out to assess whether fiber-containing materials from Brown rice, as well as Beet roots, and yogurt, were mixed by utilizing Carlyle vegetarian capsules on Wister albino mice for 2 weeks as a substitution to sources from nature. The synbiotic source of the Carlyle capsule (0.009 g/kg) and the fiber-containing group (Brown rice 3.92 g/kg, Beet roots 1.88 g/kg + yogurt 0.53 g/kg) were utilized per day for 14 days. The SGPT and CRP values showed up worthy in comparison to the control (39.33 IU/L and 0.3mg/dL), through the fiber combination had a esteem of (40 IU/L and 0.09 mg/dL). Especially, its affect on OGTT levels inside the control group was 5.2 mol./L, whereas the fiber mixture in the gather remained 7.9 mol./L. The fiber combination has a clear effect on cholesterol levels makes a different to keep up lipids inside satisfactory limits and has anti-depressant movement. The level of add up to cholesterol was 229 mg/dL, triglycerides were 148 mg/dL, HDL was 61 mg/dL, and LDL was 97 mg/dL for the control groups. In differentiate, the group accepting the fiber combination groups had lipid profiles of 161 mg/dL, 139 mg/dL, 61.14 mg/dL, and 64 mg/dL in that arrange. Subsequently, the combination of soluble and insoluble fiber is thought to be auspicious results in maintaining liver along with cardiovascular ailment. To fortify the validity of these claims, advance investigate has to be statements.
A survey on “Knowledge, attitude and lifestyle of Nonalcoholic Steatohepatitis (NASH) patients in Chattogram Division”
(Daffodil International University, 2024-05-14) Hoshen, Muhammad Farhad
The main causes of nonalcoholic steatohepatitis are known to be excessive food consumption and inactivity (NASH). Currently, the only available treatment for NASH disease is lifestyle modification. It's unclear how best to encourage behavior change in this group of people. This study aimed to characterise the relationship between patient disease knowledge, attitudes, and behaviours as well as evaluate the impact of an educational intervention. There were 171 NASH patient interviews conducted in total, where male patients were 93 and female patients was 78. Though most patients knew that the main therapy was weight loss through diet and exercise, ambiguity surrounding the diagnosis and etiology of their liver disease was a major theme. Male NASH patients' dietary habits were considerably different from those of normal male subjects, including the length of dinnertime, the quantity of rice consumed, and the frequency of consuming meat, fries, Chinese noodles, sweets, and instant food on a weekly basis. There were distinctions in the amount of rice that women ate at suppertime, how often they ate out, and how much they enjoyed sweets. Compared to female patients, male individuals with NASH exercised far less. The lifestyle preferences of NAFL and NASH were remarkably similar. There were no discernible lifestyle differences between NASH individuals who were obese and those who were not. The survey's most surprising conclusion was that men's lifestyles played a significant influence in the emergence of NASH.
A survey on Knowledge, Attitude, and Practice towards taking Proton Pump Inhibitors (PPIs) among Bangladeshi villagers
(Daffodil International University, 2024-01-22) Sarker, Mithun
It is a survey on Knowledge, Attitude, and Practice towards taking Proton Pump Inhibitors (PPIs) among Bangladeshi villagers. Out most of the villagers don’t know about proper use of PPIs. They do not know when it will be taken and why the are taken PPIs? There haven’t any awareness between most of the Bangladeshi villagers. Who don’t have any formal educational knowledge the take PPIs without doctor’s advice. They go to pharmacy and bye PPIs. They don’t know about dose of the PPIs at a time. The take their own advice. They take it after taking food. That’s why it can not work properly. In the result Most of the Bangladeshi villagers are use PPIs. Most of them are woman and who do not have any educational knowledge the use without doctors prescription. Who are Educated they know everything about PPIs. But one part of educated villagers don’t know when it will be take. They take it after taking food. That’s why it can’t work 100% or properly. They do not know about it’s demerits. They don’t have any knowledge it create some adverse effect after taking PPIs. On the other hand who are un educated, don’t have any academic knowledge they don’t have any knowledge about PPIs. They take it without doctor’s prescription. They do not know when it will be taken. And they take it randomly. They also don’t know 30-60 minutes before taking food it will be taken. That’s why there are suffering mane problems and for that reasons PPIs can not work properly. For that reason PPIs don’t it’s 100%.
A Survey on Prevalence & Treatment of Pneumonia at Hospital in Gazipur
(Daffodil International University, 2024-07-01) Islam, Md. Mazharul
This survey investigates the prevalence and treatment protocols for pneumonia at a hospital in Gazipur. Pneumonia, a significant public health concern, poses a substantial burden on healthcare systems worldwide, particularly in low- and middle-income regions. As per survey, 90% of respondents retorted that they have been very familiar about Pneumonia, although 8% designated that they have been lacked familiarity with the illness. Conferring to this investigation, 67% participants replied that they have been affected with Pneumonia & 33% responder replied that they haven’t affected with Pneumonia. 39% participants replied that they have been diagnosed Pneumonia with one time in their life time, 31% responders retorted that they have been diagnosed Pneumonia with two time in their life time. 36% participants replied that they have been experienced shortness of breath, 34% responders retorted that they have been experienced Cough-may cough up yellow or green mucus. Conferring to the exploration most of the responders (50%) replied that they have been experienced 1-2 week symptoms before seeking medical attention. 30% responders replied that they have been sought first attention from hospital, 25% participants retorted that they have been sought first attention from local clinic, 20% responders replied that they have been sought first attention from pharmacy. Conferring to the survey, 42% responders replied that doctor suggested chest X-ray, 25% responders retorted that doctor suggested blood test. 35% responders replied that they have been taken antibiotic, 28% responders retorted that they have been taken corticosteroid, 22% participants retorted that they have been taken leukotriene receptor antagonist (LTRA). In conclusion, the findings of this survey provide a comprehensive overview of pneumonia's prevalence and treatment in Gazipur, serving as a valuable resource for healthcare providers and policymakers
A Survey on Prevalence and Management of Asthma and Allergic Inflammation in the Dhaka Medical College & Hospital
(Daffodil International University, 2024-06-06) Imtiaz, Shad Mohammad
Asthma and allergic rhinitis are significant global public health concerns, affecting millions and heavily burdening healthcare systems. This study presents findings from a comprehensive survey assessing the current status of asthma and allergic rhinitis in Dhaka, Bangladesh. Using a cross-sectional study design, data were collected from a representative sample of Dhaka's population. Participants completed a structured questionnaire that included demographic information, symptoms of asthma and allergic rhinitis, environmental factors, and healthcare-seeking behaviors. Notably, 34% of individuals reported an asthma diagnosis, with 20% experiencing severe and persistent chest tightness. Additionally, 45% of participants frequently encountered secondhand smoke, wheezing, and coughing. Wheezing caused discomfort in 30% of respondents, and 20% were regular smokers. The study also revealed that 37% of respondents lived or worked in areas with high air pollution, and 33% resided in cloudy areas. Regarding treatment, 36% of respondents used inhalers, and 29% took oral medications for relief from asthma and allergic rhinitis. These findings highlight the urgent need for early diagnosis, effective treatment, and patient education to mitigate the impact of these conditions in Dhaka.
A Survey on Prevalence, Complication & Treatment of Postpartum Depression at Ishwardi Health Complex, Pabna
(Daffodil International University, 2024-07-06) Akter, Sumya
Background: Postpartum depression (PPD) is a significant public health issue affecting mothers globally, impacting maternal and child health. Understanding the prevalence, complications, and treatment approaches is essential for developing effective interventions. Objective: This study aims to investigate the prevalence of postpartum depression, associated complications, and the treatment modalities available and utilized by mothers at Ishwardi Health Complex in Pabna. Methods: A cross-sectional survey was conducted among postpartum women attending the Ishwardi Health Complex, Pabna. Data were collected using structured questionnaires assessing demographic variables. Results: Among the participants 60% of respondents stated that they were quite knowledgeable about postpartum depression. This poll revealed that 40% of respondents said they had been impacted by postpartum depression, whereas the majority of respondents (60%) said they had not been affected. In this investigation, majority of the responders 40% replied that they have been felt their symptoms is less than 2 weeks. 26% of respondents described experiencing crying too much. Furthermore, 15% of participants indicated suffering from depressed mood or severe mood swings, while 21% stated they had experienced Difficulty bonding with your baby. In this survey, 35% participants retorted that prolonged depression is the most common complication associated with untreated PPD. Among the all participants 40% replied that delay in diagnosis is the key factor that contribute to complications in PPD. Moreover, 25. 45% responders replied that doctor has been suggested Medication (antidepressants) for managing PPD. Conferring to this education, the majority of participants (89%) indicated that they were highly content with the existing treatment procedures for postpartum depression. Conclusion: There is a critical need for improved screening, increased awareness, and accessible treatment options to address this public health concern effectively.
A survey on Salmonella typhi Bacteria: its Implications, Current Situation, Preventions and Control Efforts
(Daffodil International University, 2024-01-22) Sultana, Mahima
Salmonella typhi, the causative agent of typhoid fever, continues to pose a significant global health threat, particularly in regions with inadequate sanitation and limited access to clean water. This comprehensive survey explores the implications of Salmonella typhi infections, shedding light on the current situation, preventive measures, and ongoing control efforts. The implications of Salmonella typhi infections extend beyond the immediate health impact, encompassing economic burdens, reduced workforce productivity, and strain on healthcare systems. According to the survey, most of the responders replied that they have been very familiar with Salmonella typhi infection. In this investigation most of the responders (77%) replied that they have been affected Typhoid. 53% response that they have been suffered high fever that is becoming severe and constant. Also 17% participant’s response that they have been suffered abdominal pain and 20% have been suffered higher and severe diarrhea. According to the survey, most of the participants (57%) replied that they have been taken medicine without doctor prescribing. According to the survey, most of the responders (78%) replied that they haven’t aware about complication of Salmonella typhi. In this investigation most of the responders (60%) replied that they have been known Typhoid is a contagious disease. 37% responders replied that they have been taken preventive measure as washing hands regularly, 25% replied taken safe food handling practices, 20% replied that they have been taken vaccination and also 18% taken steps as avoiding raw or undercooked foods. 35% responders said Typhoid fever may be gets worse like Pneumonia and anemia, 22% typhoid intestinal perforation (TIP), 18% gastrointestinal hemorrhage & 15% hepatitis. The survey discusses various vaccination strategies, hygiene practices, and public awareness campaigns that have proven effective in reducing the incidence of typhoid fever. By understanding the implications and addressing the challenges, stakeholders can work collaboratively to reduce the burden of typhoid fever and improve public health outcomes worldwide
A survey on the knowledge and perceptions of long term uses of proton pump inhibitors among patients with gastrointestinal disorders in Dhaka medical college hospital
(Daffodil International University, 2024-01-22) Shanta, Sanzida Sharmin
Proton pump inhibitors (PPIs) are widely prescribed medications for the management of various gastrointestinal disorders. This survey aims to investigate the knowledge and perceptions of patients with gastrointestinal disorders regarding the extended use of PPIs. The study employs a cross-sectional design, utilizing a structured questionnaire administered to a diverse sample of patients diagnosed with gastrointestinal disorders who are currently undergoing long-term PPI therapy. The survey assesses participants' awareness of the indications for PPI use, understanding of potential side effects and risks associated with prolonged usage, and their perceptions of the necessity for continued medication. In this investigation most of the responders (77%) have been affected gastrointestinal disease. Majority of the responders 44% replied they have been diagnosed gastrointestinal disease from less than one year, 31% responders replied they have been diagnosed gastrointestinal disease from 1-5 years. Among them majority participants 30% responded that they have been suffered Gastroesophageal reflux disease (GERD). Also 20% participant’s responded that they have been suffered change in normal bowel habits. According to the survey, most of the responders (78%) have been said they haven’t aware about complication of long term use of Proton Pump Inhibitor (PPI). 32% participants replied that they have been suffered Bone fractures, 25% responded suffered Clostridium difficile-associated diarrhea, and 18% replied they suffered chronic kidney disease due to long term use of Proton Pump Inhibitor (PPI). In this investigation, maximum participants 55% replied that they have been taken PPI daily, 22% replied 2-3 times a week and 18% replied 4-5 times a week taken Proton Pump Inhibitor. Majority of the participants 92% replied that they have been taken regularly PPI without doctor prescribing. Here demonstrate that 40% responders replied they have been PPI in morning empty stomach, 25% replied they have been taken PPI at night 30 min before and 30% responders taken after meal. Ultimately, this survey serves as a valuable foundation for future research and interventions aimed at enhancing patient education and understanding regarding the longterm use of proton pump inhibitors.
A survey on the Prevalence, Diagnostic Approach, Complication and Treatment of Hyperthyroidism in Dhaka Medical College & Hospital, Dhaka
(Daffodil International University, 2024-06-06) Ahmed, Tofayal
Hyperthyroidism, a condition characterized by excessive production of thyroid hormones, presentssignificant public health challenges globally, including in Bangladesh. This survey investigates the prevalence and treatment procedures of hyperthyroidism among patients at Dhaka Medical College & Hospital (DMCH). 60%, considered themselves quite knowledgeable about Hyperthyroidism. In contrast, 35% of the participants indicated that they lacked familiarity with the condition. Majority of respondents (70%) reported that they have not been impacted by Hyperthyroidism, while 30% indicated that they have been affected by the condition. 41% of respondents indicated experiencing Hyperthyroidism for a duration of 6-12 month. Additionally, 29% of participants reported enduring Hyperthyroidism for more than 2 years. As per the research findings, 33% of those surveyed noted feelings of nervousness, anxiety, and irritability. Furthermore, 30% of the participants reported experiencing a swollen neck due to an enlarged thyroid gland (goitre). Majority of the participants (55%) have been replied that doctor diagnosed Hyperthyroidism by blood test that measure level of thyroid stimulating hormone (TSH) & 37% responders replied that doctor diagnosed Hyperthyroidism by blood test that measure T4and T3 level. In this investigation, 35% participants have been replied that doctor prescribed Anti-thyroid medications, 30% retorted that doctor prescribed Surgery (thyroidectomy). Most of the participants (42%) retorted that they have been experienced itching after taken anti-hyperthyroidism medication. 35% of respondents reported that they had participated in Hyperthyroidism support or community events. This survey underscores the necessity for continuous monitoring and tailored treatment plans to enhance patient outcomes in hyperthyroidism management at DMCH.
Dengue Fever: Assessing Awareness, Current Status, and Future Perspectives – A Comprehensive Survey
(Daffodil International University, 2024-05-14) Rana, Md Sohel
The study examined dengue fever knowledge and views among 100 adults aged 20-40. This extensive poll evaluated gender, education, age, work, dengue familiarity, and personal history. The research intended to investigate public dengue knowledge and experiences to inform focused public health initiatives. A well-designed survey was given to 100 participants from diverse demographics. The poll included 15 relevant questions on dengue awareness, personal experiences, and treatment. Participants from varied backgrounds completed the online survey, bringing useful insights. 88% of individuals showed acquaintance with dengue, indicating a good overall awareness rate. Majority awareness is a good sign of illness comprehension in the studied community. The research found that 24% of the population had dengue, demonstrating its widespread prevalence. This underscores the need for dengue prevention to reduce public health risks. The study shows a variety of treatments, with paracetamol accounting for 66%. Intravenous fluids (34%), platelet transfusions (14%), and a combination of all therapeutic methods (11%) show the variety of dengue treatments. Individualized therapies for distinct demographic groups are highlighted by these findings. Knowing the incidence and treatment options helps create focused public health interventions. We conclude that this study provides a complete overview of dengue disease views among adults aged 20-40. The report praises general awareness but stresses targeted actions for the 12% who lack understanding. Preventive strategies are crucial given the 24% incidence. The different therapeutic options used emphasize the need for tailored treatments, enabling informed and focused public health programming to reduce dengue fever's effect on the assessed community.
Detection of Autism Spectrum Disorder of Children Using Machine Learning Techniques
(Daffodil International University, 2024-11-20) Fatema, Kaniz
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by a wide range of symptoms that affect an individual's social interaction, communication, and behavior. Early diagnosis and intervention play a crucial role in improving the quality of life for individuals with ASD. This thesis presents a comprehensive investigation into the analysis and detection of ASD using advanced machine learning techniques. The primary objective of this research is to develop a robust and accurate ASD screening tool that can assist in early identification. To achieve this goal, we leverage machine learning algorithms and a diverse range of data sources, including behavioral assessments, clinical records, and demographic information. The research explores the application of supervised learning, feature selection, and data preprocessing techniques to enhance the performance of ASD detection models. This thesis also delves into the development of a prototype application that combines sophisticated machine learning models with an intuitive user interface. The application enables caregivers, educators, and healthcare professionals to conduct preliminary ASD assessments efficiently and receive real-time feedback. Furthermore, the study examines the significance of feature selection and engineering in improving the interpretability of ASD detection models. It explores the potential of neural networks, support vector machines, and other state-of-the-art algorithms in achieving high diagnostic accuracy. The findings presented in this thesis contribute to the growing body of research in the field of autism spectrum disorder detection. The research outcomes have practical implications for early intervention and support for individuals with ASD, ultimately promoting better outcomes and enhanced quality of life. In conclusion, this thesis serves as a valuable resource for researchers, healthcare professionals, and stakeholders in the field of ASD. It underscores the potential of machine learning techniques in advancing the accuracy and efficiency of ASD detection and sets the stage for further research and innovation in this critical area of healthcare.
Hand, Foot, and Mouth Disease: A Questionnaire Survey on Diagnosis, Treatment, and Prevention
(Daffodil International University, 2024-06-06) Tonny, Yesmin Akter
Hand, foot, and mouth disease (HFMD) is a viral infection that typically affects children under five years old. It is typified by typical signs including oral herpes and rashes on the hands and feet. This study aims to determine the general public's awareness of hand, foot, and mouth disease (HFMD). An assessment of hand, foot, and mouth illness was created using questionnaires that were distributed one-on-one. According to the survey (31%) responders have been replied that they have idea about Hand, foot, and mouth disease. Most of the participants (69%) have been replied that they have no idea about this illness. 29% participants have been replied that they have been known causes of Hand, foot, and mouth disease. 71% of respondents, or most of them, are unaware of the illness's causes. The majority of respondents (91%) to the study stated that youngsters (ages 5-7) are more vulnerable to hand, foot, and mouth illness. According to 29% of respondents, human contact such as kissing or hugging is how the illness listed earlier is spread. Additionally, 25% and 14% of respondents indicated that they had come into contact with dung and/or touched surfaces or objects, correspondingly. Fruit drinks, citrus fruits, soda, and other acidic foods and beverages can worsen the indications of hand, foot, and mouth disease. 71% of respondents who had family members with hand, foot, and mouth disease said that their doctor had given them a throat swab test to diagnose the condition. For HFMD, there isn't a specific medical intervention. According to 88% of respondents, vitamin D can help reduce hand, foot, and mouth disease discomfort. The majority of respondents (69%), in accordance to the examination, stated that their symptoms persisted for seven days. In summary, it is possible to stop its spread by adhering to the right preventive measures.
Investigating Hemophilia Patients' Experiences and Perceptions of their Health-related well-being in Dhaka City - A Cross-Sectional Study
(Daffodil International University, 2024-05-06) Munayam, Md.
Background: Hemophilia, a rare bleeding disorder, presents significant challenges to patients' health-related well-being. Understanding patients' experiences and perceptions is crucial for optimizing their care and improving their quality of life. Methods: A cross-sectional survey was conducted among hemophilia patients in Dhaka City, utilizing structured questionnaires. Results: As per this survey, 41% of responders reported suffering from hemophilia for 1- 5 years. 29% responders have been replied that they have been suffered from hemophilia for 6-10 years. 26% replied that they have been suffered Bleeding of the mouth and gums. 25% responders replied that they have been suffered Bleeding into the joints. 55% retorted that they have been experienced 3-5 times bleeding episode per month. As per this survey most of the responders 60% retorted that their daily activities and mobility has been slightly affected due to bleeding episode. (76%) replied that their family member have been Hemophilia. Conclusion: This study sheds light on the multifaceted challenges faced by hemophilia patients in Dhaka City concerning their health-related well-being. Further research is warranted to explore additional factors influencing patients' experiences and perceptions, with the ultimate goal of developing comprehensive and patient-centered care strategies.
Investigation of In-vitro Anticancer and Pesticidal Activity of Bougainvillea spectabilis Leaves Methanolic Extract
(Daffodil International University, 2024-12-29) Maeesa, Saila Kabir
Background: This thesis contains cytotoxicity, lethality, and pesticidal tests to investigate in-vitro anticancer and pesticidal properties of the methanolic extract of Bougainvillaea spectabilis leaves. Methods: The CellTiter 96 Non-Radioactive Cell Proliferation Assay was used to assess the extract's cytotoxic activity against HeLa cells (human cervical carcinoma). The brine shrimp lethality test (BSLT) was used to conduct preliminary toxicity screening. Using Rice weevils, pesticidal activity was evaluated in a lab setting. Results: With an LD50 value of ~8.7mg/ml indicating anticancer activity and a concentrationdependent reduction in cell viability, the extract demonstrated notable cytotoxicity in HeLa cells. Strong overall toxicity was shown by the extract's 100% death rate in the BSLT. The extract's potential as a natural pesticide was demonstrated by the pesticidal assay, which showed 100% mortality. Conclusion: The results show that bioactive chemicals with significant anticancer and pesticidal effects are present in the extract of Bougainvillaea spectabilis leaves. These findings provide the groundwork for additional bioassay-guided fractionation and characterization to create new agrochemical and medicinal compounds.
"Phytochemical screening & antistress activities of the methanolic extracts of Melochia Corchorifolia leaves
(Daffodil International University, 2024-01-01) Bappy, Rakiba Akter
The present study was undertaken to evaluate the possible “phytochemical screening and antistress activities of the methanol extracts of Melochia Corchorifolia leaves” (family: Sterculiaceae. The leaf's methanol and water extracts have been shown in numerous studies to have antibacterial, antifungal, cytotoxic, and anti-cancer properties. Using conventional procedures, the methanolic extract underwent a phytochemical examination. Numerous phytoconstituents were found, including glycosides, terpenoids, alkaloids, steroids, tannins, phenols, and saponins, according to the analysis. The design research investigates the impacts of spleen anatomy, blood glucose levels, weight fluctuation, and anti stress exercise. The stress group had blood glucose levels of 10.23 ± 1.08 mmol/L and 7.43 ± 0.89 mmol/L, whereas the medicinal sample group had values of 8.9 ± 0.81 mmol/L and 11.03 ± 0.37 mmol/L, respectively. The stress group had a cortisol level of 4.17± 0.19 ug/dl, whereas the medicinal sample group and standard group had levels of 2.13± 0.30 ug/dl and 3.17± 0.18 ug/dl, respectively. Weight fluctuation for the stress group was 26.66 ± 1.20gm, whereas the sample group was 25 ±1 gm. A morphological analysis of the spleen was done in order to evaluate and compare the effectiveness of conventional and herbal medicines against the spleen mass.
Phytochemical Screening and Biological Tests of Methanol Extract of Ruellia simplex
(Daffodil International University, 2024-01-22) Tasnim, Mst. Saima
The phytochemical composition and possible biological activities of Ruellia simplex, a medicinal herb that has conventional uses, were studied. Plant material was extracted using methanol, and the resultant extract was thoroughly screened for the existence of several secondary metabolites using phytochemical analysis. Alkaloids, flavonoids, Saponin, Glycoside, and tannins were found in the results of the research, indicating the plant’s varied chemical composition. The biochemical properties of the Ruellia simplex methanol extract were then assessed using a battery of in vitro experiments and in-vivo anti-diarrheal, in-vitro thrombolytic activity, in vitro antioxidant & in vivo anthelminthic activity. Ruellia Simplex methanol extract showed adequate thrombolytic effectiveness (69%), according to this investigation. Standard ascorbic acid’s DPPH inhibitory effect displays the IC50 (9.072 μg/ml) as the positive control. The Methanol extract of Ruellia Simplex has a notable DPPH inhibitory effect, with an IC50 of 20.487 μg/ml when compared to standard. The findings of this research emphasize Ruellia simplex’s potential uses in medicine and healthcare by providing significant details on the phytochemical makeup of the plant and its biological activities. The results highlight the significance of looking for novel therapeutic compounds in natural sources and may open the door for future studies
Phytochemical Screening and Biological Tests of Methanol Extract of Ruellia simplex
(Daffodil International University, 2024-01-22) Tasnim, Mst. Saima
The phytochemical composition and possible biological activities of Ruellia simplex, a medicinal herb that has conventional uses, were studied. Plant material was extracted using methanol, and the resultant extract was thoroughly screened for the existence of several secondary metabolites using phytochemical analysis. Alkaloids, flavonoids, Saponin, Glycoside, and tannins were found in the results of the research, indicating the plant’s varied chemical composition. The biochemical properties of the Ruellia simplex methanol extract were then assessed using a battery of in vitro experiments and in-vivo anti-diarrheal, in-vitro thrombolytic activity, in vitro antioxidant & in vivo anthelminthic activity. Ruellia Simplex methanol extract showed adequate thrombolytic effectiveness (69%), according to this investigation. Standard ascorbic acid’s DPPH inhibitory effect displays the IC50 (9.072 μg/ml) as the positive control. The Methanol extract of Ruellia Simplex has a notable DPPH inhibitory effect, with an IC50 of 20.487 μg/ml when compared to standard. The findings of this research emphasize Ruellia simplex’s potential uses in medicine and healthcare by providing significant details on the phytochemical makeup of the plant and its biological activities. The results highlight the significance of looking for novel therapeutic compounds in natural sources and may open the door for future studies.
Phytochemical Screening and Scientific Exploration of Synergistic Antioxidant and Thrombolytic Potential of Methanol Extract of Acacia concinna, Terminalia arjuna & Bombax ceiba.
(Daffodil International University, 2024-07-29) Poddar, Monisa Rani
85% of deaths globally are attributable to thrombosis, a serious consequence of cardiovascular illness that can result in myocardial infarction (or heart attack) and stroke. A major contributing factor to toxicity and illness may be oxidative stress.It can harm a lot of your tissues, which over time might result in a lot of illnesses. One crucial disclaimer is that antioxidant therapy should not be used after harm has started. Objectives: To evaluate the impact on thrombolysis and antioxidants as well as the potential chemical components. Materials and Methods: For the phytochemical testing, which took place in a lab, plant material from Acacia concinna, Terminalia arjuna, and Bombax ceiba was extracted using methanol. The thrombolytic activity was carried out using the clot lysis method, and the thrombolytic test was performed. The antioxidants were screened for using the DPPH technique. Results: Acacia concinna, Terminalia arjuna, Bombax ceiba, Mixed extract-1(A+B)(Acacia concinna & Bombax ceiba),& Mixed extract-2(B+T) (Bombax ceiba & Terminalia arjuna) extract showed clot lysis percentagethe respectively 12.18%, 34.35%, 17.81%, 27.10% & 39.35%.And compeared with the control 7.33% where as standard (Streptokinase) showed a of clot lysis at 75.29%. Additionally Acacia concinna, Terminalia arjuna, Bombax ceiba, Mixed extract1(A+B),& Mixed extract-2 (B+T) extract showed antioxidant activity respectively (IC50=16.20µg/ml, 28.85µg/ml, 22.27µg/ml, 16.20µg/ml & 14.75µg/ml),compeared with the standard ascorbic acid (IC50=9.072µg/ml). A phytochemical analysis revealed a wide range of chemical components in the extract of Acacia concinna, Terminalia arjuna, and Bombax ceiba, including alkaloids, carbohydrates, tannins, glycosides, and saponins.
Survey on Analyzing Medicine Leaflets in Bangladesh:Impact,Availability,and Public Health Expectations
(Daffodil International University, 2024-05-06) Shuvo, Shakil Khan
Background: Bangladesh is one of the South Asian countries having different public health issues like child and maternal death, and outbreaks of communicable – noncommunicable diseases. The desideratum of this research is to investigate and analyze the influence of patient education pamphlets on public health in Bangladesh and to evaluate patient’s expectations, scope of development and provision of current practice of Patient Information Leaflets (PIL). Methods: The study is carried out using an online survey utilizing Google Form and through mass interviews conducted offline. A self-administered questionnaire prepared utilizing a questionnaire-based interview schedule. The entire study was built around a targeted questionnaire that was developed utilizing information from previous research on medicine information leaflets that had been done in various parts of the world as well as some general knowledge about medicine information leaflets. The questionnaire was prepared divided questions in four parts of Personal Information, Knowledge About Medicine Information Leaflet, Usability & Room for Improvement of Medicine Information Leaflet and Health Benefit. Results: Data was collected from 984 people of different ages, genders, demographic locations, education levels and occupation. Among them, 699 people know about it and 340 people read it regularly. Around 41% of people read it to learn about dose but 49% of people find it hard to understand. Although 59% of people admit PIL helps them a lot to understand the medication but 38% thought further improvement is needed. 23% of the population currently use digital media to gain information regarding medicine but 44% of the population prefer it over traditional media as 35% of the population thought digital media helps them to compare between brands. 38% of the population read PIL before buying a medicine but for 28% it influences on their buying decision. Conclusion: Patient Information leaflet makes a great impact on people's understanding of medicine and a more patient oriented leaflet can improve the overall public health scenario in Bangladesh.