Browsing by Author "Ripa, Farhana Alam"

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A review on antidiabetic property of mangrove plants
(BRAC University, 2023-09) Akter, Rashni; Ripa, Farhana Alam
At present, diabetes mellitus encompasses an extensive number of metabolic disorders characterized by chronic hyperglycemia, representing a significant global health concern. According to the mangrove plant it has many antidiabetics property which reduces the sugar level in the body. For this particular scenario, antioxidants assume a significant role in enhancing the condition of individuals with diabetes and minimizing the complication. In contrast, oxidative stress happens within the human body when there is an imbalance in how it produces of reactive oxygen species. We can review that mangrove plant has several phytochemicals derived antioxidant activity which minimizes the complication of diabetics and related to the oxidative stress. These compounds have shown promising potential in the treatment of diabetes and its related complexity, which are often linked to oxidative stress. Hence, the application of mangrove plants holds promise in efficiently handling the issues associated with diabetes and its associated difficulties. The present review investigates the correlation between oxidative stress and diabetes, along with the potential ofmangrove plants in mitigating the effects of diabetes and its accompanying issues connected with oxidative stress.
A review on antidiabetic property of mangrove plants
(BRAC University, 2023-09) Akter, Rashni; Ripa, Farhana Alam
At present, diabetes mellitus encompasses an extensive number of metabolic disorders characterized by chronic hyperglycemia, representing a significant global health concern. According to the mangrove plant it has many antidiabetics property which reduces the sugar level in the body. For this particular scenario, antioxidants assume a significant role in enhancing the condition of individuals with diabetes and minimizing the complication. In contrast, oxidative stress happens within the human body when there is an imbalance in how it produces of reactive oxygen species. We can review that mangrove plant has several phytochemicals derived antioxidant activity which minimizes the complication of diabetics and related to the oxidative stress. These compounds have shown promising potential in the treatment of diabetes and its related complexity, which are often linked to oxidative stress. Hence, the application of mangrove plants holds promise in efficiently handling the issues associated with diabetes and its associated difficulties. The present review investigates the correlation between oxidative stress and diabetes, along with the potential of mangrove plants in mitigating the effects of diabetes and its accompanying issues connected with oxidative stress.
A review on Pandanus Tectorius (Keya) and its major pharmacological activities
(BRAC University, 2022-10) Rehan, Shamik; Ripa, Farhana Alam
The value of medicinal plants as a source of treatment has been recognized since the dawn of mankind. This review research focused on the little tree Pandanus tectorius (P. tectorius), which is used in traditional medicine to cure a number of diseases. Other body and organ functions, such as renal function and lipid metabolism, may be affected by diabetes. Pandanus tectorius has promising pharmacological properties against diabetes mellitus, owing to its extraordinary behavior. This study discovered that this plant not only enhances biological function but also reduces the severity of many drugs' side effects.
A review on pharmacological properties of vitis vinifera
(BRAC University, 2022-03) Tushar, Mahbub Alam; Ripa, Farhana Alam
Among different fruit plants, the grape plant is widely regarded as one of the essential sources of phenolic compounds, including resveratrol, phenolic acids, kaempferol, quercetin, catechins, proanthocyanins, etc. Several studies have demonstrated that those polyphenols or nutraceuticals obtained from the plant grapes have health benefits, including lowering the incidence of cardiovascular disease or cancer, improving cognition and neuronal function with aging and neurodegenerative diseases, and exhibiting antiallergic, antitumor, anti-inflammatory, antidiabetic, and antimicrobic properties. These polyphenols can also help us live longer lives by improving our health conditions, delaying the aging process, preventing chronic diseases, increasing our life expectancy, or supporting the structure and function of our bodies. The wine, grape seeds, and grape skins contain a significant amount of those phenolic compounds. Wine is regarded as a particularly excellent source of grape phenolic compounds. Research on polyphenols and pharmacological properties of Vitis vinifera have been summarized in this article.
A review on the pharmacological properties of Heritiera fomes
(BRAC University, 2020-12) Das, Shawdik; Ripa, Farhana Alam
Heritiera fomes is one of the vital plants in the mangrove forest of Bangladesh. It is widely used by the local people in many purposes including domestic and medical uses. The purpose of this project is to highlight the different pharmacological properties of H. fomes (Sundori) plant. This plant has a number of medicinal properties such as, anticancer activity, antidiabetic activity, antioxidant activity, anti-nociceptive activity, anti-obesity, antimicrobial activity. Moreover, medicinal properties like, anti-MRSA activity, anti-diarrhea activity, micro-nutrient activity are also found in this plant which makes it an ideal medicinal plant among other plants found in Sundarban mangrove forest. These pharmacological properties helps to discover many medicines and also beneficial for the treatment of many diseases. Scientist believes that H. fomes has many more medicinal properties which are yet to be found. The advantageous pharmacological properties and there effect on many diseases have been emphasized in these work.
A review on Tinospora cordifolia and its immunomodulatory activities
(BRAC University, 2020-12) Islam, Md. Rabiul; Ripa, Farhana Alam
Medicinal plants have always been considered as a valuable source of treatment since the ancient times. This review paper was done focusing on Tinospora cordifolia and its immunomodulatory properties. T. cordifolia is a large climbing shrub having many pharmacological properties and this medicinal plant has a great demand among the folk people of the Indian subcontinent. Different parts of T. cordifolia consist of many pharmacologically active compounds like alkaloids, phenols, glycosides, steroids, terpenoids, tannins, carbohydrates and other unique compounds having immunomodulatory, anti-diabetic, anti inflammatory, hypotensive, scizonticidal, antibacterial, antifungal, antioxidant, antidiarrheal and many other properties. This plant can play a significant role in the modulation of the immune system as several components of this plant can increase the phagocytic activity of macrophage, antibody production, nitric oxide production, production of cytokines, lymphocyte proliferation, chemotactic index, plaque forming cell production and many other immune system modifying activities. The finding of this study is that this plant can increase the efficiency of the immune system.
Acute toxicity assessment of Polyalthia Suberosa leaves
(BRAC University, 2025) Erena, Shakea Naznin; Ripa, Farhana Alam
Medicinal plants have been essential to human health care for millennia and remain a significant source of novel medicines. A significant segment of the population in several developing nations depends on plant-based traditional medicine for basic health care. This study sought to assess the oral acute toxicity of the leaf extract from Polyalthia suberosa in experimental mice to ascertain its safety profile. This study was conducted to observe if the leaves have any potential toxicity in oral administration according to the Organization for Economic Co-operation and Development (OECD, 423). Here mice received a single oral administration of the methanolic extract at a dosage of 2000 mg/kg body weight. The animals were monitored for 14 days for neurological and physiological changes and mortality. No fatalities or notable signs of toxicity were observed, indicating that the extract has a substantial safety margin. Our finding shows that the lethal dose (LD₅₀) of P. suberosa extract is under 2000 mg/kg; hence, it could be safe for the novel therapeutic drugs.
Analgesic and CNS depressant activities of methanolic shell extract of Nypa fruticans Wurmb fruit in Swiss albino mice
(BRAC University, 2023-08) Lubaba, Rafiya Rafa; Ripa, Farhana Alam
The study explored the analgesic and CNS depressant activities of a methanolic shell extract from Nypa fruticans Wurmb fruit. Methanolic shell extract of N. fruticans Wurmb fruit was acetic acid induced technique was used to test the analgesic efficacy in mice. An evaluation of CNS depressant activity used the hole cross test. Different doses (200, 400, and 600 mg/kg) were administered to mice, and results indicated significant dose-dependent analgesic and CNS depressant activities (p<0.05). The extract exhibited enhanced analgesic effects, achieving 51.16% inhibition at 600 mg/kg, whereas the standard drug Indomethacin achieved 79.54% inhibition. At 600 mg/kg, the extract reduced locomotor activity and exploratory behavior, similar to standard drug diazepam. These findings highlighted the notable analgesic and CNS depressant activities of the methanolic shell extract from N. fruticans Wurmb fruit.
Anti-inflammatory and anti-diarrheal effects of methanolic extracts of seeds and peel of Nephelium longan fruits in rats
(© 2013 Iranian Journal of Pharmacology and Therapeutics, 2013) Ripa, Farhana Alam; Habib, Afroza
Herbal medicines are playing a vital role in the remedy of numerous diseases. Preliminary phytochemical screening of the methanolic extracts of seeds (MNLS) and peel (MNLP) of Nephelium longan revealed the presence of alkaloids, tannins and flavonoids. For antidairrheal screening, we have followed Castoroil- induced method whereas to check anti-inflammatory property, we used carrageenan-iduced rat paw edema in Long-Evan rats. Two doses (250 and 500 mg/Kg) of the extracts and one dose of indomethacin as reference was used. Both extracts significantly (p < 0.05) reduced the formation of oedema induced by carrageenan in a dose-depending manner. MNLP and MNLS also exhibited anti-diarrheal action in dosedepending manner and all the results were found to be significant (p < 0.05) in comparison to loperamide. The outcomes indicate the potent anti-inflammatory and anti-diarrhoeal effects of N longan extracts on living models which are comparable with those of standard drugs such as indomethacin and loperamide respectively and support their conventional uses as medicine.
Antidiabetic and antidiarrheal effects of the methanolic extract of Phyllanthus reticulatus leaves in mice
(© 2014 Elsevier (Singapore) Pte Ltd, 2014-06) Ripa, Farhana Alam; Khatun, Mst. Hajera; Nesa, Mst. Luthfun; Islam, Rafikul; Al mamum; Kadir, Shahin
Objective To assess the anti-diabetic and antidiarrheal activity of methanolic extract of Phyllanthus reticulates (P. reticulates) leaves in an animal model. Methods Phytochemical screening of methanolic extract of P. reticulatus leaves has been performed. Antidiabetic activity have been done by OGTT, normoglycemic hyperglycemia and alloxan induced diabetic mice. Plant extracts (150 mg/kg and 300 mg/kg, b.w.) were administered orally in fasting glucose loaded mice with regard to normal control and in alloxan induced (110 mg/kg body weight i.p.) diabetic mice in comparison with reference drug Metformin hydrochloride (100 mg/kg) during 7 day test period. Antidiarrheal test was conducted by castor oil and magnesium sulfate. Results Findings confirmed that the continuous post-treatment for 7 days with both extracts showed significant (P < 0.05) hypoglycemic activity in OGTT, normoglycemic and alloxan induced mouse models. Castor oil and Magnesium sulfate induced diarrheal test of the extract (200 and 400 mg/kg) has given significant effect in compairing to control diarrheal group. Conclusion Methanolic extract of P. reticulatus leaves have shown significant antidiabetic and antidiarrheal properties.
Antioxidant and hypoglycemic effect of Flacourtia jangomas
(BRAC University, 2019) Hasan, Md Rakibul; Ripa, Farhana Alam
Flacourtia jangomas known as lukluki fruits is assuming to have antioxidant and hypoglycemic profile. In order to prove that, we have chosen the methanolic extract of Flacourtia jangomas fruits for assessing the antioxidant and hypoglycemic activity. So, DPPH (1, 1 diphenyl-2-picryl hydrazyl) test was done for percentage scavenging of methanolic extract of F.jangomas in contrast to Ascorbic acid for antioxidant activities. This study found that the IC50 value for methanolic extract of F.jangomas fruits was 53.71μg/ml as compared to strong antioxidant ascorbic acid IC50 46.71μg/ml which is indicator towards its antioxidant properties. In terms of hypoglycemic study, oral glucose test was conducted for 1-3 hours on swiss albino mice taking 10% glucose as a reference drug and the declination of glucose level for MFJ600 is 11.17±2.36g which is close to standard 9.48±1.84g after 1 hour and the rest of the result were sequential. So, Flacourtia jangomas fruit has antioxidant and hypoglycemic properties which may direct revolution in medicinal science in assessing diabetes.
Antioxidant and hypoglycemic effect of Nypa Fruticans wurmb fruit shell
(BRAC University, 2024-01) Alam, Saosan Salmin; Ripa, Farhana Alam
Plant extract-based natural medicines are becoming more and more popular as a substitute for synthetic drugs, which raises safety concerns. This study examined Nypa fruticans's hypoglycemic and antioxidant impact. We have chosen to assess the antioxidant and hypoglycemic qualities of the methanolic extract of N. frutican’s fruit shell (MNF) to demonstrate this. So, DPPH (1, 1 diphenyl-2-picryl hydrazyl) test was done for the percentage scavenging of methanolic extract of N.fruticans in contrast to Ascorbic acid for antioxidant activities This study shows that the N.fruticans fruit shell sample's methanolic extract has an IC50 value of 50.59 g/ml, which is indicative of its antioxidant properties, compared to the potent antioxidant ascorbic acid's IC50 value of 44.11 g/ml. Swiss albino mice were given 10% glucose solution as a reference medication and allowed to undergo the Oral glucose tolerance test (OGTT) for one to three hours. Following an hour, the NFS600 glucose level declined to 12.17±2.36, which is almost identical to the usual 8.58±1.84. The remaining outcomes followed one another. Because of this, the methanolic shell of N. fruticans has antioxidant and hypoglycemic properties that may help advance medical research in the area of diabetes diagnosis.
Assessment of CNS depressant activity of Nypa Fruticans Wurmb fruit pulp
(BRAC University, 2024-02) Anika, Tasmim Farhana; Ripa, Farhana Alam
Nypa fruticans Wurmb (Family: Arecaceae) or Nipa palm is locally known as “Golfol” in Bangladesh which is of great interest now for its multiple uses. The present investigation was carried out to evaluate the CNS depressant activity of methanolic fruit pulp extract of N. fruticans (MNF) on Swiss albino mice model by following the standard protocol of the hole cross test at three different dosages (200, 400 and 600 mg/kg body weight) against the standard diazepam. Here, MNF extract showed maximum suppression of motor activity (only 3.40 ± 0.49 number of movements) at 600 mg / kg after 120 minutes (p< 0.05). Therefore, the current study's findings indicate potent and dose-dependent CNS depressing action of MNF extract which can be used as a new source for the development of novel sedative-hypnotic drug. However, further investigation is required to find out the responsible phytoconstituents for the CNS depressant activity of MNF.
Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats
(© 2014 Tropical Journal of Pharmaceutical Research) Ripa, Farhana Alam; Ibn Morshed, Mahmud Tareq; Afsana-Al-Sharmin; Papon, Shahed Bulbul; Islam, Md Rafiqul; Sheikh, Zara
Purpose: To assess the central nervous system (CNS) depressant, analgesic and antidiarrheal activities of the dried seed crude extracts of Dimocarpus longan Lour in rodents. Methods: Selected pharmacological effects of the ethanol (ENLS), petroleum ether (PELS), chloroform (CHLS) and ethyl acetate (EALS) extracts of D. longan fruit seeds were investigated. CNS depressant activity was evaluated by open field and hole cross tests; analgesic activity by acetic acid-induced writhing test and formalin-induced licking test; and anti-diarrheal activity was assessed in castor oil and magnesium-induced diarrhea rat model. The extracts were given orally in a rat model at doses of 200 and 300 mg/kg body weight. Normal saline served as control in all experiment. In CNS depressant test, diazepam (1 mg/kg) was used as reference drug while indomethacin (10 mg/kg) and loperamide(2 mg/kg) were used as standard drugs in analgesic and antidiarrheal tests, respectively. Results: In hole cross method, EALS showed the most effective depressant effect, viz, 1.17±0.17 for 200 mg/kg dose and 0.83±0.31 number of movements for 300 mg/kg dose after 120 min (p < 0.01), whereas in the open field test, all the extracts exhibited significant (p < 0.01) depressant effect in relation to positive control, diazepam. In acetic acid-induced pain test, PELS gave the lowest number of writhing (2.83±0.307) and the highest inhibition (88.45 %, 300 mg/kg dose) which was statistically significant. All the extracts also significantly (p < 0.01) suppressed licking activity in both phases of the formalin-induced licking test, in contrast to indomethacin. In the antidiarrheal tests, diarrheal suppression was highest at 300 mg/kg dose for all the extracts, compared with loperamide in both castor oil and magnesium sulphate induced diarrhea model. Conclusion: The extracts of Dimocarpus longan tested demonstrated significant CNS depressant, analgesic and antidiarrheal activities in a rodent model.
Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats
(© 2014 Tropical Journal of Pharmaceutical Research) Ripa, Farhana Alam; Ibn Morshed, Mahmud Tareq; Afsana-Al-Sharmin; Papon, Shahed Bulbul; Islam, Md Rafiqul; Sheikh, Zara
Purpose: To assess the central nervous system (CNS) depressant, analgesic and antidiarrheal activities of the dried seed crude extracts of Dimocarpus longan Lour in rodents. Methods: Selected pharmacological effects of the ethanol (ENLS), petroleum ether (PELS), chloroform (CHLS) and ethyl acetate (EALS) extracts of D. longan fruit seeds were investigated. CNS depressant activity was evaluated by open field and hole cross tests; analgesic activity by acetic acid-induced writhing test and formalin-induced licking test; and anti-diarrheal activity was assessed in castor oil and magnesium-induced diarrhea rat model. The extracts were given orally in a rat model at doses of 200 and 300 mg/kg body weight. Normal saline served as control in all experiment. In CNS depressant test, diazepam (1 mg/kg) was used as reference drug while indomethacin (10 mg/kg) and loperamide(2 mg/kg) were used as standard drugs in analgesic and antidiarrheal tests, respectively. Results: In hole cross method, EALS showed the most effective depressant effect, viz, 1.17±0.17 for 200 mg/kg dose and 0.83±0.31 number of movements for 300 mg/kg dose after 120 min (p < 0.01), whereas in the open field test, all the extracts exhibited significant (p < 0.01) depressant effect in relation to positive control, diazepam. In acetic acid-induced pain test, PELS gave the lowest number of writhing (2.83±0.307) and the highest inhibition (88.45 %, 300 mg/kg dose) which was statistically significant. All the extracts also significantly (p < 0.01) suppressed licking activity in both phases of the formalin-induced licking test, in contrast to indomethacin. In the antidiarrheal tests, diarrheal suppression was highest at 300 mg/kg dose for all the extracts, compared with loperamide in both castor oil and magnesium sulphate induced diarrhea model. Conclusion: The extracts of Dimocarpus longan tested demonstrated significant CNS depressant, analgesic and antidiarrheal activities in a rodent model.
Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats
(© 2014 Tropical Journal of Pharmaceutical Research) Ripa, Farhana Alam; Ibn Morshed, Mahmud Tareq; Afsana-Al-Sharmin; Papon, Shahed Bulbul; Islam, Md Rafiqul; Sheikh, Zara
Purpose: To assess the central nervous system (CNS) depressant, analgesic and antidiarrheal activities of the dried seed crude extracts of Dimocarpus longan Lour in rodents. Methods: Selected pharmacological effects of the ethanol (ENLS), petroleum ether (PELS), chloroform (CHLS) and ethyl acetate (EALS) extracts of D. longan fruit seeds were investigated. CNS depressant activity was evaluated by open field and hole cross tests; analgesic activity by acetic acid-induced writhing test and formalin-induced licking test; and anti-diarrheal activity was assessed in castor oil and magnesium-induced diarrhea rat model. The extracts were given orally in a rat model at doses of 200 and 300 mg/kg body weight. Normal saline served as control in all experiment. In CNS depressant test, diazepam (1 mg/kg) was used as reference drug while indomethacin (10 mg/kg) and loperamide(2 mg/kg) were used as standard drugs in analgesic and antidiarrheal tests, respectively. Results: In hole cross method, EALS showed the most effective depressant effect, viz, 1.17±0.17 for 200 mg/kg dose and 0.83±0.31 number of movements for 300 mg/kg dose after 120 min (p < 0.01), whereas in the open field test, all the extracts exhibited significant (p < 0.01) depressant effect in relation to positive control, diazepam. In acetic acid-induced pain test, PELS gave the lowest number of writhing (2.83±0.307) and the highest inhibition (88.45 %, 300 mg/kg dose) which was statistically significant. All the extracts also significantly (p < 0.01) suppressed licking activity in both phases of the formalin-induced licking test, in contrast to indomethacin. In the antidiarrheal tests, diarrheal suppression was highest at 300 mg/kg dose for all the extracts, compared with loperamide in both castor oil and magnesium sulphate induced diarrhea model. Conclusion: The extracts of Dimocarpus longan tested demonstrated significant CNS depressant, analgesic and antidiarrheal activities in a rodent model.
Central nervous system depressant, analgesic and antidiarrheal effects of the seed extracts of Dimocarpus longan lour in rats
(© 2014 Tropical Journal of Pharmaceutical Research) Ripa, Farhana Alam; Ibn Morshed, Mahmud Tareq; Afsana-Al-Sharmin; Papon, Shahed Bulbul; Islam, Md Rafiqul; Sheikh, Zara
Purpose: To assess the central nervous system (CNS) depressant, analgesic and antidiarrheal activities of the dried seed crude extracts of Dimocarpus longan Lour in rodents. Methods: Selected pharmacological effects of the ethanol (ENLS), petroleum ether (PELS), chloroform (CHLS) and ethyl acetate (EALS) extracts of D. longan fruit seeds were investigated. CNS depressant activity was evaluated by open field and hole cross tests; analgesic activity by acetic acid-induced writhing test and formalin-induced licking test; and anti-diarrheal activity was assessed in castor oil and magnesium-induced diarrhea rat model. The extracts were given orally in a rat model at doses of 200 and 300 mg/kg body weight. Normal saline served as control in all experiment. In CNS depressant test, diazepam (1 mg/kg) was used as reference drug while indomethacin (10 mg/kg) and loperamide(2 mg/kg) were used as standard drugs in analgesic and antidiarrheal tests, respectively. Results: In hole cross method, EALS showed the most effective depressant effect, viz, 1.17±0.17 for 200 mg/kg dose and 0.83±0.31 number of movements for 300 mg/kg dose after 120 min (p < 0.01), whereas in the open field test, all the extracts exhibited significant (p < 0.01) depressant effect in relation to positive control, diazepam. In acetic acid-induced pain test, PELS gave the lowest number of writhing (2.83±0.307) and the highest inhibition (88.45 %, 300 mg/kg dose) which was statistically significant. All the extracts also significantly (p < 0.01) suppressed licking activity in both phases of the formalin-induced licking test, in contrast to indomethacin. In the antidiarrheal tests, diarrheal suppression was highest at 300 mg/kg dose for all the extracts, compared with loperamide in both castor oil and magnesium sulphate induced diarrhea model. Conclusion: The extracts of Dimocarpus longan tested demonstrated significant CNS depressant, analgesic and antidiarrheal activities in a rodent model.
Evaluation of analgesic activity of different parts of Heritiera fomes on swiss albino mice
(BRAC University, 2022-03) Alam, Fowzia; Ripa, Farhana Alam
Heritiera fomes is a common mangrove species carrying many novel phytochemicals and is traditionally used for its therapeutic activities. This study inspected the analgesic activity of different parts of ethanolic crude extracts of H. fomes using Swiss albino mice. The investigation included two methods- acetic acid- induced writhing method and formalin induced pain test. The crude extracts were administered in mice at a dose of 250mg/kg and 500mg/kg body weight to calculate percent inhibition and was compared with standard indomethacin drug. All the results were statistically significant (P<0.01) and the ethanol extract of H. fomes leaves and roots showed effective therapeutic result of 84.67% and 83.54% inhibition. Other extracts also showed assuasive analgesic activity in a dose dependent manner compared to the standard indomethacin drug. To conclude, overall investigation indicated that the ethanol extracts of different parts of H. fomes carry potential analgesic therapeutic agents to control pain.
Evaluation of anti-diarrheal activity of methanolic flesh extract of Flacourtia jangomas on mice
(BRAC University, 2022-11) Susmita, Nusrat Jahan; Ripa, Farhana Alam; Chowdhury, Namara Mariam
"Flacourtia jangomas is rare fruit, rarely found in hill tracks of Bangladesh. This is a less researched fruits but have many phytochemical constituent. It contain many pharmacological activity as well. The fact that F. jangomas is now thought to be an excellent reservoir of chemicals such phenol, tannin, alkaloids, flavanoids, and terpenoids that may be a better source to cure diarrhea is a major driving force behind this research. This study tested the F. jangomas flesh in vivo antidiarrheal effect on Swiss albino mice. In order to compare the test results, Loperamide was utilized as the reference medication. Three concentrations of F. jangomas (15mg/ml, 30mg/ml and 45mg/ml) of each extract showed antidiarrheal activity. The results have been elucidated as number of feces in every 1hr. The number feces counted till 4hrs. The antidiarrheal activity of methanolic flesh per hour until 4hrs extract of F.jangomas at 100,200and 300mg/kg concentration showed number of feces time respectively is 10.83, 9.67 and 8.65 in 4hrs. F. jangoma showed the effectiveness of antidiarrheal activity 14.52%, 23.68%and 32.91% respectively. All the result were significant (P<0.001) for the antidiarrheal activity. This study highlights the significance of F. jangomasin's use as an antidiarrheal agent and the need for additional research to identify the active ingredient that causes this effect."
Evaluation of anti-microbial activity and minimum inhibitory concentration of Flacourtia jangomas fruits
(BRAC University, 2023-02) Rahman, MD. Atikur; Ripa, Farhana Alam
The objective of this study was to determine the particular antibacterial components of Flacourtia jangomas fruit. The antimicrobial screening used the Kirby-Baurer disk diffusion technique and the Broth dilution method, both of which are considered "standard procedures." Kirby-Baurer disk diffusion technique shows that at a concentration of 500g/disc, methanol extract demonstrated exceptional efficacy against the vast majority of test microorganisms. Bacillus cereus QL 29 performed the best among the test organisms, whereas Sacharomyces cerevaceae* fungus exhibited the least susceptibility to the extract. In Minimum Inhibitory Concentration test highest MIC value is 256 μg/ mL which shows 7 bacteria and lowest MIC result is 128 μg/ mL which is showed by 5 bacteria where the test was done on 12 bacteria. The Flacourtia jangomas fruit has been shown to exhibit significant antibacterial activity in both method.