Evaluation of anti-diarrheal activity of methanolic flesh extract of Flacourtia jangomas on mice

Abstract

"Flacourtia jangomas is rare fruit, rarely found in hill tracks of Bangladesh. This is a less researched fruits but have many phytochemical constituent. It contain many pharmacological activity as well. The fact that F. jangomas is now thought to be an excellent reservoir of chemicals such phenol, tannin, alkaloids, flavanoids, and terpenoids that may be a better source to cure diarrhea is a major driving force behind this research. This study tested the F. jangomas flesh in vivo antidiarrheal effect on Swiss albino mice. In order to compare the test results, Loperamide was utilized as the reference medication. Three concentrations of F. jangomas (15mg/ml, 30mg/ml and 45mg/ml) of each extract showed antidiarrheal activity. The results have been elucidated as number of feces in every 1hr. The number feces counted till 4hrs. The antidiarrheal activity of methanolic flesh per hour until 4hrs extract of F.jangomas at 100,200and 300mg/kg concentration showed number of feces time respectively is 10.83, 9.67 and 8.65 in 4hrs. F. jangoma showed the effectiveness of antidiarrheal activity 14.52%, 23.68%and 32.91% respectively. All the result were significant (P<0.001) for the antidiarrheal activity. This study highlights the significance of F. jangomasin's use as an antidiarrheal agent and the need for additional research to identify the active ingredient that causes this effect."