Browsing by Author "Persson, Lars Ake"
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Item A community based, randomized, controlled trial to assess the efficacy of iron and/ or Zinc or a micronutrient mix supplementation to reduce anemia and morbidity and to improve growth and development in Bangladeshi infants(1999) Baqui, Abdullah H.; Fuchs, Georgr; Zaman, K; Persson, Lars Ake; Arifeen, Shams El; Hamadini, Jena; Wahed, M.A.; Yunus, Md.; Shahid, Nigar; Chakraborty, J.Item A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: interactions between iron and zinc(2003) Lind, Torbjorn; Lönnerdal, Bo; Stenlund, Hans; Ismail, Djsuhar; Seswandhana, Rosadi; Ekström, Eva-Charlotte; Persson, Lars AkeItem Addressing the public heath crisis caused by arsenic contamination of drinking water in Bangladesh [book](Washington, DC: World Bank, 2001. 64 p., 2001) Kaufmann, Rachel; Sorensen, Birte; Rahman, Mahfuzur; Streatfield, Kim; Persson, Lars AkeItem An effectiveness study of haemophilus influenzae type b vaccine(2000) Baqui, Abdullah H.; Arifeen, S. EL; Zaman, K.; Islam, Manirul; Shahid, N.; Hossain, S.; Rahman, M.; Persson, Lars AkeItem Arsenic exposure in pregnancy: a population-based study in Matlab, Bangladesh(2006) Vahter, Marie E.; Li, Li; Nermell, Barbro; Rahman, Anisur; Arifeen, Shams El; Rahman, Mahfuzar; Persson, Lars Ake; Ekstrom, Eva-CharlotteItem Arsenic in tube well water and health consequences(2001) Persson, Lars AkeItem Breaking the Cycles of Malnutrition: Are Pregnancy Nutrition Interventions Effective(2007-09-02T09:11:33Z) Persson, Lars AkeItem Breast-feeding protects against celiac disease(2002) Ivarsson, Anneli; Hernell, Olle; Stenlund, Hans; Persson, Lars AkeItem Do side-effects reduce compliance to iron supplementation: a study of daily- and weekly-dose regimens in pregnancy(International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), 2002) Hyder, S.M. Ziauddin; Persson, Lars Ake; Ekstrom, Eva-Charlotte; Chowdhury, A.M..R.Side-effects of iron supplementation lead to poor compliance. A weekly-dose schedule of iron supplementation rather than a daily-dose regimen has been suggested to produce fewer side-effects, thereby achieving a higher compliance. This study compared side-effects of iron supplementation and their impact on compliance among pregnant women in Bangladesh. These women were assigned to receive either weekly doses of 2x60 mg iron (one tablet each Friday morning and evening) or a daily dose of I x60 mg iron. Fifty antenatal care centres were randomly assigned to prescribe either a weekly- or a daily-supplementation regimen (86 women in each group). Side-effects were assessed by recall after one month of supplementation and used for predicting compliance in the second and third months of supplementation. Compliance was monitored using a pill bottle equipped with an electronic counting device that recorded date and time whenever the pill bottle was opened. Of five gastrointestinal side-effects (heartburn, nausea, vomiting, diarrhoea, or constipation) assessed, vomiting occurred more frequently in the weekly group (21 %) than in the daily group (11 %. p<0.05). Compliance (ratio between observed and recommended tablet intake) was significantly higher in the weekly supplementation regimen (93%) than in the daily-supplementation regimen (61 %, p<0.05). Overall, gastrointestinal side-effects were not significantly associated with compliance. However. the presence of nausea and/or vomiting reduced compliance in both regimens, but only among women from the lower socioeconomic group. In conclusion, weekly supplementation of iron in pregnancy had a higher compliance compared to daily supplementation of iron despite a higher frequency of sideeffects. The findings support the view that gastrointestinal side-effects generally have a limited influence on compliance, at least in the dose ranges studied. Efforts to further reduce side-effects of iron supplementation may not be a successful strategy for improving compliance and effectiveness of antenatal iron supplementation.Item Do side-effects reduce compliance to ironsupplementation:a study of daily-and weekly-dose regimens in pregnancy(2002) Hyder, S.M. Ziauddin; Persson, Lars Ake; Chowdhury, A.M.R.; Ekström, Eva-CharlotteItem Effects of weaning cereals with different phytate contents on hemoglobin, iron stores, and serum zinc: a randomized intervention in infants from 6 to 12 mo of age(2003) Lind, Torbjorn; Lönnerdal, Bo; Persson, Lars Ake; Stenlund, Hans; Tennefors, Catharina; Hernel, OlleItem Efficacy and trial effectiveness of weekly and daily iron supplementation among pregnant women in rural Bangladesh: disentangling the issues(2002) Ekstrom, Eva-Charlotte; Hyder, S.M. Ziauddin; Chowdhury, A. Mushtaque R.; Chowdhury, Sadia A.; Lonnerdal, Bo; Habicht, Jean-Pierre; Persson, Lars AkeItem Efficacy and trial effectiveness of weekly and daily iron supplementation among pregnant women in rural Bangladesh: disentangling the issues(The American Journal of Clinical Nutrition, 2002) Ekstrom, Eva-Charlotte; Hyder, S.M. Ziauddin; Chowdhury, AMR; Chowdhury, Sadia A.; Lonnerdal, Bo; Habicht, Jean-Pierre; Persson, Lars AkeBACKGROUND: According to our current understanding, iron absorption with weekly iron supplements is not higher than that with daily supplements (ie, there is no mucosal block). However, community-based trials have repeatedly shown that a weekly regimen is as effective as a daily one. Furthermore, when differences in absorption are found, they are commonly smaller than would be expected on the basis of differences in the amount of iron provided. The possibility of differential compliance between the regimens needs to be evaluated to explain these findings. OBJECTIVE: Taking compliance into account, we compared the efficacy and trial effectiveness of weekly and daily iron supplementation during pregnancy. DESIGN: In Bangladesh, 50 antenatal centers were randomly assigned to prescribe either 2 doses of 60 mg Fe once weekly or 1 dose of 60 mg Fe/d. Compliance was monitored by using a pill bottle equipped with an electronic counting device. Hemoglobin concentrations were measured at baseline and after 4, 8, and 12 wk of supplementation. RESULTS: There was no differential effect per iron tablet between weekly and daily regimens. A 12-wk daily regimen (68% compliance) produced a small but significantly greater hemoglobin response than did the weekly regimen (104% compliance). The first 20 tablets consumed produced most of the effect; after 40 tablets, there was no further response. CONCLUSIONS: There was no evidence of a mucosal block in the daily regimen. Over 12 wk, 50% of the amount of iron in a daily regimen was sufficient for maximum hemoglobin effect. The weekly regimen provided a large part of this amount, explaining the limited difference in effect. It appears that the current international recommendation for iron supplementation in pregnancy is higher than necessary.Item Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants(2004-10) Black, Maureen M.; Baqui, Abdullah H.; Zaman, K.; Persson, Lars Ake; Arifeen, Shams El; Le, Katherine; McNary, Scot W.; Parveen, Monowara; Hamadani, Jena D.; Black, Robert E.Item Side-effects have limited impact on compliance to iron supplementation among pregnant women in rural Bangladesh(abstract)(2001-03) Ekstrom, E-C; Hyder, Ziauddin; Chowdhury, Mushtaque; Persson, Lars AkeItem Simultaneous weekly supplementation of iron and zinc is associated with lower morbidity due to diarrhea and acute lower respiratory infection in Bangladeshi infants(2003) Baqui, Abdullah H.; Zaman, K.; Persson, Lars Ake; Arifeen, Shams El; Yunus, Mohammad; Begum, Nazma; Black, Robert E.Item The Bangladesh arsenic calamity and reproduction : does arsenic contamination of drinking water result in fetal wastage, intrauterine growth retardation, neonatal deaths and impaired cognitive development, and to what extent can nutrition intervention reduce the risk(Dhaka: International Centre for Diarrhoeal Diseases Research, Bangladesh; 2002, 2002) Persson, Lars AkeItem The Swedish coeliac disease epidemic with a prevailing twofold higher risk in girls compared to boys may reflect gender specific risk factors(2003) Ivarsson, Anneli; Persson, Lars Ake; Nyström, Lennarth; Hernell, OlleItem Violence against women increases the risk of infant and child mortality: a case-referent study in Nicaragua(2003) Asling-Monemi, Kajsa; Peña, Rodolfo; Ellsberg, Mary Carroll; Persson, Lars Ake