Browsing by Author "Islam, M. Anwarul"

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An Impressive Thrombolytic and Analgesic Effect Has Been Exhibited in the Methanolic Extract of Hygroryza Aristata Leaves
(Pharmacologyonline, 2020) Hossain, Md. Sarowar; Rashid, Md. Mamunur; Azad, Md. A.K.; Rahman, Md. Mizanur; Ferdous, Md. Wahed; Islam, M. Anwarul
Hygroryza aristata is the significantly most important traditional medicinal plant practitioners all over the country since long years. Seeds are cooling and astringent to urinary tract; useful in biliousness. By the use of this plant only a few investigations was done like: anti-inflammatory and antioxidant. The purpose of the study is to determine the thrombolytic and analgesic activity of Hygroryza aristata extract. Phytochemical screening of the methanolic extract of whole plant of Hygroriza Aristata indicates the presence of alkaloids, carbohydrates, flavonoid, glycoside, and steroid. In thrombolytic assay, methanolic extract of the Hygroriza aristata leaves exhibited a promising effect compared standard drug Streptokinase. Here, the extract exhibited 63% (for 100 mg) clot lysis activity whereas; Streptokinase exhibited 82% (for 30,000 I.U). The analgesic activity of the methanolic leaf extract of Hygroriza aristata was also observed by acetic acid induced writhing in mice. This writhing was markedly reduced with increase of the amount of extract at 250 mg/kg (63.1%) and 500 mg/kg (70.24%) respectively. Here, Diclifenac-Na 10 mg/kg (54.76%) was used as a standard drug. Thus, we can assume that, Hygroriza aristata plant have a promising effect of thrombolytic and analgesic activity that shoshowed a ways of inventing new lead compound having such type of pharmacological effects respectively.
In Vivo Evaluation of Analgesic, Anti-Inflammatory and Antidiabetic Activities of Methanol Extract of Carallia Brachiata L. Leaves
(Scopus, 2020-04-30) Islam, M. Anwarul; Hossain, Md. Sarowar; Azad, Md. A.K.; Rashid, Md. Harun-Or; Rahman, Md. Mofizur
Most of analgesic and anti-inflammatory drugs cause hyperacidity and peptic ulcer. The present study was carried out to evaluate analgesic, anti-inflammatory and anti-diabetic activities of methanol extract of Carallia brachiata L. leaves on experimental mice. Carallia brachiata L. leaves showed significant analgesic effects (*p<0.01) on acetic acid induced writhing of mice compared to the control group where diclofenac sodium was used as standard.Carallia brachiata L. leaves decreased thecarrageenan induced paw edma notably (*p<0.05 and **p<0.01) compare to control group in which standard was diclofenac sodium. The methanol extract of Carallia brachiata L. leaves was administered intraperitoneally as a single dose of 150 mg/kg body weight to alloxan induced diabetic rats and found to reduced blood lipid level (Total cholesterol and Triglycerides) significantly (*p<0.05). The extract also exhibited correlation of altered biochemical parameters viz., SGOT and SGPT levels in diabetic rates. The effect of plant extract was compared with the standard drug metformin. The phytochemical screening tests indicated that the different constituents such as saponins, tannins, triterpenes, alkaloids and flavonoids etc. were present in the plant which hasanalgesic, anti-inflammatory and anti-diabetic properties but further study neededto evaluate the mechanism of action of antidiabetic activities of Carallia brachiata L
In Vivo Evaluation of Analgesic, Anti-inflammatory and Antidiabetic Activities of Methanol Extract of Carallia Brachiata L. Leaves
(Pharmacology online, 2020-04-30) Islam, M. Anwarul; Hossain, Md. Sarowar; Azad, Md. A.K.; Rashid, Md. Harun-Or; Rahman, Md. Mofizur
Most of analgesic and anti-inflammatory drugs cause hyperacidity and peptic ulcer. The present study was carried out to evaluate analgesic, anti-inflammatory and anti-diabetic activities of methanol extract of Carallia brachiata L. leaves on experimental mice. Carallia brachiata L. leaves showed significant analgesic effects.
Investigation of Analgesic, Anti-Inflammatory and Antidiabetic Effects of Phyllanthus Beillei Leaves H
(Scopus, 2021) Hossain, Md. Sarowar; Islam, M. Anwarul; Rahman, Md. Anisur; Tamanna, Sonia
The current study was carried out to explore the analgesic, anti-inflammatory and anti-diabetic potential of methanol extract of Phyllanthus beilei H. The analgesic activities were determined by acetic acid induced writhing test in mice. The oral administration of doses 500 mg/kg of methanol extract of Phyllanthus beilei H. inhibited 42.22% of writhing movements compared to standard drug diclofenac-Na 94.28% writhing movement inhibition induced by acetic acid. Anti-inflammatory effect of ethyl acetate extract was determined after oral administration of 1% Carrageenan, paw edema in mice. Mice treated with ethyl acetate extract of Phyllanthus beilei H. (500 mg/kg) moderately decreased in paw volume at 180 min and 240 min compared with mice of control group. Here, pronounced effects were observed in extract group 34.36% inhibition of paw edema compared to that of Standard Group 55.13% inhibition of paw edema. In the Oral glucose tolerance test the control group of mice exhibited higher blood glucose levels whereas, mice treated with extract (500 mg/kg) showed significant decrease in blood glucose level after 30 mins and 120 mins compared with control group of mice.
Phytochemical, Anti-Microbial and Cytotoxic Studies on Leaves Extract of Phyllanthus Beillei H
(Scopus, 2021) Hossain, Md. Sarowar; Islam, M. Anwarul; ghosh, Mrinal Kanti; Rashid, Md. Harun-Or; Tamanna, Sonia
Microbial resistant is getting dangerous day by day. To find a new antimicrobial source is very essential. The current research study was designed to assess the antimicrobial activity of methanol extract of Phyllanthus Billie H. by disc diffusion method. By measuring zone of inhibition mild antimicrobial activity of Bacillus subtilis was found and compared with the standard Ciprofloxacin. From the result, it can be concluded that the Phyllanthus beillei H. plant may be a source of antimicrobial constituents. The plant extract also demonstrated promising cytotoxic activity against brine shrimps nauplii. The value of LC50 of methanol extract of Phyllanthus Billie H. was 2.4119 mg/mL which compared with the LC50 value of the standard (0.0171mg/mL). The overall results indicate a strong cytotoxic activity of this plant.