Investigation of Analgesic, Anti-Inflammatory and Antidiabetic Effects of Phyllanthus Beillei Leaves H

Abstract

The current study was carried out to explore the analgesic, anti-inflammatory and anti-diabetic potential of methanol extract of Phyllanthus beilei H. The analgesic activities were determined by acetic acid induced writhing test in mice. The oral administration of doses 500 mg/kg of methanol extract of Phyllanthus beilei H. inhibited 42.22% of writhing movements compared to standard drug diclofenac-Na 94.28% writhing movement inhibition induced by acetic acid. Anti-inflammatory effect of ethyl acetate extract was determined after oral administration of 1% Carrageenan, paw edema in mice. Mice treated with ethyl acetate extract of Phyllanthus beilei H. (500 mg/kg) moderately decreased in paw volume at 180 min and 240 min compared with mice of control group. Here, pronounced effects were observed in extract group 34.36% inhibition of paw edema compared to that of Standard Group 55.13% inhibition of paw edema. In the Oral glucose tolerance test the control group of mice exhibited higher blood glucose levels whereas, mice treated with extract (500 mg/kg) showed significant decrease in blood glucose level after 30 mins and 120 mins compared with control group of mice.