Phytochemical screening and evaluation of hypoglycemic activity of citrus sinensis peel extract

Abstract

Orange has been traditionally used as an adjuvant in different diseases including diabetes, tuberculosis, asthma and hypertension. Phytochemically, entire plant contains flavonoids, saponinss, tannins, glycosides, limonene, citral, neohesperidin, naringin, rutin, rhamnose, eriocitrin, and vitamin-C. An examination on the impacts of convergences of peel extract from Citrus sinensis in hyperglycemic Albino mice uncovered the glucose lowering activity of Citrus sinensis . In this test, the methanolic extract of the fruit peel was assessed in two dosage regimen- 200mg/kg and 400mg/kg, regarding the regulation of glucose incited diabetes mellitusand both the doses were find to lower the serum glucose level , uncovering the antihyperglycemic activity of the methanolic extract of Citrus sinensis peel. In the Brine Shrimp Lethality Toxicology study, the bioactivity of the extract was found sound and the phytochemical screening of the methanolic extract of the peel showed presence of different constituents like flavonoids, alkaloids etc.