Insilico Structural and Functional Annotation of Hypothetical Protein From Candida auris

Abstract

Candida auris is fungal pathogen that grow as yeast in the family of Saccharomycetaceae. It is worldwide outbound as a multidrug resistant fungal pathogen. This fungi can cause any type of diseases and can also spread easily among people and environment. The infection of this fungi can effect brain, blood, heart and can cause bloodstream infection and even death. So the main objective of this study is to find a structure and function of a hypothetical protein (GBL47790) that is important for Candida auris by using in silico method. Many computational tools has been used to identify domain family and function, secondary structure, 3D model and the overall quality of this protein is also checked by computational tools. Functional annotation reveal that this cytoplasmic protein is required for proper rRNA processing and maturation of 28s and 5.8s rRNA and catalyze the formation of peptide bond. This function seems quite important for the cell of Candida auris. So further study about this protein can lead to design an antifungal medication that will treat diseases caused by Candida auris. Keyword: Multidrug resistant, hypothetical protein, computational tools, functional annotation, antifungal medication.