Helicobacter pylori and immune evasion in gastric carcinogenesis

Abstract

Helicobacter pylori is found in approximately half of the global population, often without causing any symptoms of disease. Its infection is a significant public health concern and has been extensively researched for its role in gastric carcinogenesis, primarily due to its ability to evade the body’s immune system. This review will examine the complex relationship between H. pylori and the host’s immune response, emphasizing how immune evasion contributes to the prolonged infection that precedes cancer. By evading the immune system, this bacteria establishes a persistent infection and creates an environment favorable to cancer development. In conclusion, this article seeks to provide an overview of current knowledge and recent discoveries regarding H. pylori’s immune evasion strategies and their impact on the progression of gastric cancer. The information presented could aid in more effective methods for managing and preventing H. pylori-related gastric cancer.