An overview of phage therapy as an alternative option of MDR bacteria and possible future of COVID-19 treatment

Abstract

One of the greatest difficulties that humanity will confront in the near future is antibiotic resistance. (Bacterio) phage therapy is a valuable therapeutic alternative to antibiotics, and while the concept is almost as ancient as phage discovery, antibiotic discovery and development in the mid-twentieth century hampered its widespread adoption. The global problem of multidrug-resistant bacterial infections demand immediate action, including the invention of antibiotic-free medicines. Phages can down regulate excessive inflammatory reactions relevant in clinical course of COVID-19. This paper is focused on the existing regulatory framework to which such therapy should adhere and reviewed the current obstacles and shortcomings in scientific development for bacteriophage therapy and assume that the PT may participate a therapeutic role in terms of COVID-19 treatment.