A review on solid dispersion : a substitute approach for poorly water soluble drug

Abstract

The solid dispersion has become a momentous solubilization technology for poorly water soluble drugs.It is usually two component system of drug polymer, which interacts between the drug design and its performance. Solid dispersion in water-soluble carriers have interacted a means of developing the dissolution rate and bioavailability of the hydrophobic drugs. The aim of this present study is to compare the solubility of different drugs with the increased polymer concentration. The solid dispersion is stable under accelerated storage conditions.PVP K30 brings out a way to enhance the solubility and dissolution rate of the certain drug. Solid dispersions have attracted considerable interest as an important means of mounting dissolution rate with various methodologies. The main focus of this article is on advantages, disadvantages, developing various methods and categorization of the solid dispersion. There are various carriers which have been used in the solid dispersion technology and this has been focused in this article.