Study on Spectrum of Liver Dysfunction in Type-2 Diabetic Patients in Bangladesh

Abstract

This study was carried out in Rajshahi Diabetic Association Hospital, Department of Medicine, Rajshahi Medical College Hospital and Department of Hepatology, Bangubandhu Sheikh Mujib Medical University, Dhaka, over last two years to evaluate the liver function tests among type-2 diabetic patients and to see the extent and severity of abnormalities of liver function tests. We have enrolled 100 (one hundred) diagnosed type-2 diabetic patients and 100 apparently healthy people. All of those study population were free from taking any hepatoxic drugs and free from any preexisting liver disease. This exclusion was done thorough clinical examination and relevant investigations. In our study mean serum bilirubin (mg/dl), Alanine Aminotransferase (U/L), Aspartate Aminotransferase (U/L), S albumin (gm/dl) level and prothrombin time (sec) were 0.7372±0.3118, 39.00±24.21, 26.42±10.40, 4.10±0.513, 16.46±2.78 respectively among type-2 diabetic patients, where as 0.5063±0.1831, 28.26±6.67, 18.90±4.75, 4.12±0.277, 14.23±1.04 respectively among normal people. All these difference were statistically significant. (P=<0.05, <0.001, <0.001, <0.05 and <0.01 respectively). Serum Alkaline phosphate level was 89.61±25.59 in type-2 diabetic patients and 96.83± 16.34 which was statistically not significant (P=>0.05). The prevalence of abnormal serum bilirubin, Alanine Aminotransferase, Aspartate Aminotransferase, Alkaline phosphatase, prothrombin time and S. albumin were 5.17%, 31.03%, 5.17%, 5.17%, 43.10% and 10.34% respectively in type-2 diabetic patients and 00%, 02%, 00%, 02%, 03% and 00% respectively in normal people. All the LFTs were mildly abnormal except 06 patients had moderate elevation of Alanine Aminotransferase, 08 patients had moderately prolonged PT, and 02 patients had moderately decreased S. albumin of type-2 Diabetic patients. All Abnormalities of normal people were mild. A high proportion of patients with type-2 diabetes mellitus had abnormal liver function tests.