Anti-tubercular activity of novel indole and indane moiety containing derivatives: a review

Abstract

Tuberculosis (TB), a global epidemic, is creating critical situations like MDR, XDR or HIV TB which is causing death to millions of people. The demand of developing specific drugs who work through selective pathway and inhibit the mechanism of particular enzyme or bind with specific sites is not only what it needs to take drug discovery to another level, but also the solution to billions of mass people’ problem. Through a vigorous study, impressive information was found about the anti-tubercular activity, in vitro and in vivo study results against various TB strains and clinical isolates by compounds who are indane and indole moiety containing derivatives. Moreover, these different classes of agents showed different working mechanisms with enhanced activity as compared to currently using standard drugs. Though some lacking were observed, further intensive study and analysis of certain molecules like indane-2-carboxamides can lead towards the next big thing in TB research.