A Pharmacological Investigation on the Central Nervous System (CNS) Activity of Petroleum Ether Extract of Syzygium samarangense Leaves

Abstract

Syzygium samarangense, plant of Myrtaceae family has been used as a traditional medicine for the cure of many diseases in different parts of the world such as stomatitis, diarrhea, diabetes etc. The objective of the current study was to evaluate the Central Nervous System (CNS) activity of Petroleum Ether extract of the leaves of Syzygium samarangense plant in Swiss albino mice models. The leaves were powdered and then soaked in Petroleum Ether to prepare the extract. At two doses, 100 mg/kg and 200 mg/kg body weight respectively, the activity was tested by using two experiments namely, Open field test and Hole board test. In both the experiments, significant (p<0.001) decrease in locomotion activity in the mice models was observed in a dose-dependent manner when compared with the standard drug, Diazepam. Therefore, it can be said that this plant can be a potential candidate for the development of drugs acting on the Central Nervous System (CNS) in near future.