Development of Microcapsule (Combination of Diclofenac and Rabeprazole) With a Mini Review

Abstract

Due to its advantages of being biodegradable and biocompatible, polymeric carriers have been widely used in therapeutic drug delivery system formulations. One of the most accepted systems for control release is microencapsulation. This research aims to develop a novel Diclofenac sodium and Rabeparzole combo medication. Also, read several articles to determine which technique is the most effective. The rabeprazole was loaded on the pellets' surface so that it would release quickly and counteract the acid secretion caused by diclofenac. The most often used polymer is HPMC, and the most commonly used technique is ionic gelation, which has the greatest average effectiveness, according to this short review (90 percent ). HPMC (3% ) and Na-alginate are utilized in this formulation (3 percent ). The pellets were brown and sphere-shaped after being loaded with rabeprazole.