In-Vitro Evaluation of Cholinesterase Inhibitory and Antioxidant Activities of Tamarindus indica for the Treatment of Alzheimer’s Disease

Abstract

Oxidative stress and low amount of neurotransmitter specially acetylcholine are main characteristics of Alzheimer’s disease (AD), which is a progressive neurodegenerative disease. Prolonging the function of acetylcholine by inhibiting acetylcholinesterase or butyrylcholinesterase enzyme and reducing oxidative stress with antioxidants are effective treatment therapy of AD. Tamarindus indica is a well-known medicine plant with a variety of medicinal uses. In this study we examined cholinesterase inhibitory activity and antioxidant activity of tamarind leaf and bark extract. Cholinesterase inhibitory activity with IC50 of 188.67 μg/ml and 176.30 μg/ml for acetylcholinesterase and butyrylcholinesterase enzyme respectively suggested that it possesses a good source of enzyme inhibitor. In conclusion, we can say Tamarindus indica provide not only Cholinesterase inhibitory activity but also antioxidant activity which can be useful for further research to get potential molecule from it.