Rationality and Reality in the Use of Antiulcer Drugs

Abstract

A gastro-protective medication such as PPI,H2 Blockers,Antacids or others ulcer protective is found in one out of every four prescriptions written in out-patient departments.Only when there is avalid reason for prescribing these medictions should they be used.In a tertiary care hospital setting,evaluate the appropriateness and rationality of gastro-protective agent prescriptions.The study is based on a systematic review of the rational use of antiulcer medications.We gathered data for this project using online platforms like google scholars, pubmed, scopus or others.After doing the research It has been observed that almost all NSAIDs drugs like Aspirin, Neproxane, Clopidogrel, Diclofenac etc are associated to ulcer-inducing effects and other than a very few number of drugs which are responsible for ulcer like Anticoagulants, Serotonin, Corticosteroids, Methotrexate etc.While others,such as Nitric-Oxide Donors (CINODs), Nebivolol etc are linked to ulcer healing effects and most common class of gastro-protective agents that are being used frequently is Proton Pump Inhibitors(PPIs).This present study also found that most of the drugs has no negative impact on GI tract.Patients may suffer the repercussion of irrational usage of gastro-protectants because clinicians prescribe them without examining the need for them.To reduce the overuse of gastro-protectants,a rational drug prescribing policy must be implemented in all settings.So,we should be more careful to prevent the irrational use of anti-ulcerant drugs.