In Vitro Assessment of Cholinesterase Inhibitory and Antioxidant Activities of Osmunda Claytoniana for the Treatment of Neurodegenerative Disorder

Abstract

Oxidative stress and low level of neurotransmitter are main characteristics of Alzheimer’s disease (AD), a progressive neurodegenerative disease. Prolonging the function acetylcholine by inhibiting acetylcholinestarase or butylrylcholinesterase enzyme and reducing oxidative stress with antioxidant are most effective treatment therapy of AD .Osmunda claytoniana is an well-known medicine plant with a variety of medicinal uses. In this study we examine cholinesterase inhibitory activity as well as antioxidant activity of dried root and rhizomes methanolic extract. Both cholinergic inhibitory activity and antioxidant activity of various fractions suggested that, this crude methyl extract whole plant have moderate cholinesterase inhibitory activity with moderate antioxidant activity which can be used as a lead to most prominent drug for the symptomatic treatment of AD.