EFFECT OF CINNAMON CASSIA EXTRACTS ON HYPERGLYCEMIA AND RENAL FUNCTION IN STREPTOZOTOCIN INDUCED DIABETIC MICE

Abstract

Background: Diabetes mellitus (DM) is defined as a group of metabolic diseases manifested by hyperglycemia which results from defects in insulin production and/or insulin action. The present study was conducted to demonstrate the diabetogenic effect of Streptozotocin in Mice. Conventional drug treatment for diabetes mellitus carries risks that lead to many adverse effects such weight loss, hypoglycemia and many others. Asian countries including India, Bangladesh and Nepal are rich in natural resources and medicinal plants useful in the treatment of diabetes. To investigate the antidiabetic or anti-hyperglycemic effect and renal profile restoration effect of the Cinnamon cassia extract on Streptozotocin induced diabetes in experimental mice. The extract of cinnamon cassia was tested for its efficacy in Streptozotocin at a dose 100 mg/ kg of body weight induced diabetic mice. Aim of the study: To investigate the effect of Cinnamon cassia extracts on hyperglycemia, and renal profile in Streptozotocin induced diabetic mice. Methods: Thirty six male Swiss albino mice were kept in six different groups and each group have six male Swiss albino mice for 21days. Group T0 served as normal controls; Group T1 Streptozotocin induced 100 mg/ kg of body weight served as positive control mice,; Groups T2, T3 and T4 mice were also Streptozotocin induced 100 mg/ kg of body weight and mice treated with 300 mg/kg, 400 mg/kg and 500mg/kg of Cinnamon extracts (70% ethanol), respectively; and Group T5 were induced mice Streptozotocin 100 mg/ kg and treated with 5mg/kg Glibenclamide drug. The effect of extracts on hyperglycemia, and renal function were tested by chemistry analyzer. Results were analyzed using one way ANOVA at a 5% level of significance. Results: The fasting blood glucose level was significantly (p<0.05) reduced at 400mg/kg and 500mg/kg of Cinnamon extract concentration as compared to the diabetic group. It also reduces urea and creatinine in induced diabetic mice. Conclusion: Reduction in the fasting blood glucose, urea and creatinine by Cinnamon extract indicates that it has anti-hyperglycemic, and renal failure restoration effect in Streptozotocin induced diabetic mice.