Comparative Analysis of in Vitro Release Kinetics Among Sultolin®, Ventolin®, Brodil®, and Salbutal®

Abstract

Background: The purpose of this research work was to determine the in vitro release profile kinetics of four brands (Sultolin, Vento lin, Brodil and Salbutal) of salbutamol tablet of Bangladesh. Method: Ten tablets from each brand were taken to perform thickness test, weight variation test, friability test, and hardness test individually. Another two tablets from each brand were taken to do the dissolution test. Thickness tests were done using the Vernier Calipers. Weight variation tests were done using electronic weighing balance. Friability tests were done in the Roche Friabilator and hardness tests Monsanto Hardness Tester. The dissolution test was performed using dissolution tester (RC6, Vanguard Pharmaceuticals, USA). After dissolution test of the four brands absorbances were compared with the standard solution of crude salbutamol sulphate. Result: The average thickness of Sultolin, Ventolin, Brodil and Salbutal were found 8.l7mm, 8.42mm, 9.77mm and 6.32mm respectively. The % friability of Sultolin, V entolin , Brodil and Salbutal were 0.37, 0.17, -0.14, -0.10 respectively. The mean hardness values of Sultolin, Vento lin, Brodil and Salbutal were 10.007N, 11.64N, 14.72 ~ and 13.04N respectively. Average weights of Su1tolin, Ventolin, Brodil and Salbutal \!Jere found 0.17103gm, 0.20097 gm, 0.19688gm and 0.10086gm respectively. No brand met the absorbance of standard salbutamol sulphate. Conclusion: After conducting all the tests to determine various parameters, it has been found that, release profile kinetics of Sultolin, Ventolin, Brodil and Salbutal differed a lot from each other and also from the standard.