Review on CRISPR in cardiac repair

Abstract

This thesis investigates the transformative potential of CRISPR-Cas9 technology in the realm of cardiac repair. Since cardiovascular illnesses are the leading cause of morbidity and mortality globally, innovative strategies are necessary. Acknowledged for its precision in gene editing, CRISPR has potential as a therapeutic approach for cardiac tissue damage and dysfunction. This research delves into the molecular aspects of CRISPR-mediated modifications, emphasising their role in altering significant genes associated with heart regeneration and repair pathways. This study meticulously reviews the literature to shed light on the efficacy and safety of CRISPR therapies in promoting cardiomyocyte regeneration. This paper aims to add to the expanding discourse on therapeutic applications of CRISPR technology, ultimately advancing an understanding of the technology's potential to improve heart repair methods and ultimately reduce the burden of cardiovascular disorders.