Role of Pyroptosis in Cancer and Its Therapeutic Regulation

Abstract

Pyroptosis is mainly considered a gasdermin-regulated cell death mechanism characterized by cellular lysis and the release of several pro-inflammatory factors. Nowadays, pyro ptosis has notably been gained extensive attention from clinicians and researchers. However, current studies report that down regulation of pyro ptosis-mediated cell death plays a significant role in developing multiple cancers. Increasing studies also suggest that pyro ptosis can impact all stages of carcinogenesis. Inducing pyrophoric cellular death could be a promising therapeutic option for managing and regulating multiple cancers in the near future. Our current review highlights the molecular and morphological features of pyro ptosis and its potential roles in various cancers. In addition, we have also highlighted the biological characteristics and significances of GSDMD and GSDME and their critical functions in cancer progression, management and regulation.