Relationship of Hardness and Invitro Release Profile of Different Brands of Indapamide (SR) Tablet Available in Bangladesh

Abstract

Purpose: The objective of this research work was to evaluate the relationship between hardness and in vitro release profile of different brands of Indapamide(SR) tablet available in Bangladesh. Method: Three different brands of Indapamide(SR) tablets namely Repress(SR), Hypen(SR) and Indapa(SR) marketed by Square Pharmaceuticals ltd. Opsonin Pharma Ltd and Drug International respectively were collected from the market and evaluated the hardness and dissolution profile of these tablets. The release profile of Indapamide(SR) was investigated by using the method inscribed in Appendix XII B: Dissolution tests for tablets and capsules of British Pharmacopoeia. Hardness of these tablets were measured by"hardness tester (Veego, Germany) and dissolution of the taken samples were investigated using (RC6, Vanguard Pharmaceuticals, USA) dissolution tester to evaluate the relationship between the hardness of the tablet and the rate of dissolution. Result: The mean hardness value of the Indapamide(SR) tablets were found. Repress(SR) 110.37 N, Hypen(SR) 59.91 Nand Indapa(SR) 15.09 N and the rate of dissolution of these different brands of Indapamide was found Repress(SR) 0.00016 mg. ml , Hypen(SR) 0.00018 mg/ml and Indapa(SR) 0.0018 mg/ml when the absorbance \\as measured at 275 nm. Conclusion: There is a direct relation between the hardness of the tablet and the rate of dissolution. The dissolution rate was inversely proportional to the hardness of the tablet.