A review on Gene therapy for the treatment of heart failure

Abstract

Heart failure is a complex, fatal syndrome significantly affecting the quality of life, increasing cost and social burden. As a result, reducing its social and financial impact has been as a top global health priority. Researchers are considering gene therapy as a powerful emerging tool to significantly prolong heart failure patients’ life. New vectors are being studied, novel delivery methods are being proposed and innovative targets are being identified for treating heart failure by gene therapy. Some modification and improvement are yet to be done in this field to make it an effective treatment option for patients. More than 64 million people suffer from heart failure worldwide. Hence, an urgent need to cure this disease has emerged. The goal of this review is to demonstrate the different vectors used, delivery methods and targets and to provide a comprehensive understanding of the current landscape of gene therapy in treating heart failure.