In-vitro Comparative Dissolution Study of Different Brands (Alcet, Clarigen, Lecet, Lozin) of Levocetirizine Dihydrochloride with respect to Seasonix

Abstract

The aim of the present study was to evaluate and compare dissolution pattern of locally branded drug products of Levocetirizine Dihydrochloride available in Bangladesh with the brand of Levocetirizine Dihydrochloride (seasonix) marketed by Incepta Bangladesh Ltd. Seasonix is one of the renowned antihistamine drug of Bangladesh. Branded drugs are expensive than locally marketed drug. Substitution of drugs is very essential for the people of under developing country. Four different brands of Levocetirizine tablets which are available in Bangladesh like Alcet, Lecet, Lozin,Clarigen as well as Seasonix were collected from a reputed pharmacy store. Two tablets from each of the brands were used for the in-vitro dissolution study. Cumulative drug release was measured up to 50 minutes for all the brands. All the brands were compared with the reference brand (Seasonix). Differential factor,f1and similarity factor, f2 were determined. No significant difference was observed during in-vitro drug release pattern of brandAlcet, Lecet, Lozin, Clarigenwith the reference brand. Here it was found the values of f1 are 12.19, 2.9, 4.9 and 33.10 but here range is 0-15 acceptable. And the similarity factor it was seen that the values of f2 are 49, 73.87, 25.47 and 69.82. So it is acceptable.In conclusion, further investigations are needed to evaluate better dissolution study.