[6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Lepr db/db type 2 diabetic mice

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dc.contributor.authorSamad, Mehdi Bin
dc.contributor.authorMohsin, Md Nurul Absar Bin
dc.contributor.authorRazu, Bodiul Alam
dc.contributor.authorHossain, Mohammad Tashnim
dc.contributor.authorMahzabeen, Sinayat
dc.contributor.authorUnnoor, Naziat
dc.contributor.authorMuna, Ishrat Aklima
dc.contributor.authorAkhter, Farjana
dc.contributor.authorKabir, Ashraf Ul
dc.contributor.authorHannan, J M A
dc.date.accessioned2020-12-02T05:03:04Z
dc.date.available2020-12-02T05:03:04Z
dc.date.issued2020-11-02
dc.description.abstract[6]-Gingerol, a major component of Zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. Endocrine signaling is involved in insulin secretion and is perturbed in db/db Type-2 diabetic mice. [6]-Gingerol was reported to restore the disrupted endocrine signaling in rodents. In this current study on Leprdb/db diabetic mice, we investigated the involvement of endocrine pathway in the insulin secretagogue activity of [6]-Gingerol and the mechanism(s) through which [6]-Gingerol ameliorates hyperglycemia.
dc.identifier.otherhttps://ar.iub.edu.bd/handle/11348/530
dc.identifier.urihttps://ar.iub.edu.bd/handle/11348/530
dc.language.isoen
dc.publisherNational Library of Medicine
dc.sourceIUB Academic Repository
dc.subjectGLP-1
dc.subjectGLUT4
dc.subjectGlycogen synthase 1
dc.subjectLeprdb/db mice
dc.subjectRab10
dc.subject[6]-Gingerol
dc.title[6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Lepr db/db type 2 diabetic mice
dc.typeArticle

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