A Predictive Analysis to Explore Common Key Pathways Between Aplastics Anemia and Fanconi Anemia

Abstract

Aplastic’s Anemia reduces the number of blood cells in the human body and is a serious disorder of the bone marrow. When oxygen-carrying tissue in the human body and blood clotting platelets, but sometimes bone marrow fail, one of the reasons for this is a genetic condition is called Fanconi Anemia. We collected all dataset from NCBI to identify common genes between Aplastic’s Anemia (AA) and Fanconi Anemia (FA).We found 37 common genes by using VENNY online tools. We found Protein-Protein Interaction network from Cytoscape. We found three cluster network from Protein-Protein Interaction network. According to the degree score, we have identify 10 hub genes (DTL,BUB1,KIF14,FANCI,SKP2,PF4,PPBP,SPARC,ACTN1,RCHY1 ) from ProteinProtein Interaction network. These 10 hub genes are responsible for causing Aplastic’s Anemia (AA) and Fanconi Anemia (FA) diseases. These all of hub genes are cured by applying drug it is possible to rid of these two diseases (Aplastic’s Anemia and Fanconi Anemia) at the same time.