Study of Pharmacological Activities of Methanolic Extract of Phyla Nodiflora

Abstract

Purpose: The research work was carried out to determine the pharmacological activities of methanolic extract of Phyla Nodiflora. Method: Methanolic extract was administered orally to the animal model (Swiss albino) and the effects were determined by comparing with respect to control group which were treated with 5% CMC. For every experiment positive control was used. Different experiments were used to determine the pharmacological profile which was Collected from internationally published publications and journals. Result: The Laxative Effect was evaluated by Charcoal meal GI transit test where methanolic extract at dose of 800 mg/kg body weight increase the charcoal transit which compare with positive control. The CNS activity was evaluated by open field method and hole board test. In the open field method and hole board experiment the crude extract of Phyla Nodiflora. (200mg/kg,400mg/kg & 800mg/kg) dose dependently reduces the number of peripheral locomotion, central locomotion and leaning in the open field test and reduces the number of head dipping and head poking in the hole board test. The reduction is significant (***p<0.001) when it is compared to the standard drug. The aim of the study was also to investigate the possible toxicity of the plant Phyla Nodiflora and especially to establish the safety of the methanolic extract of this plant by focusing on its acute and chronic toxicity in mice. Conclusion: After summarize all the results it can say that Phyla Nodiflora may have several pharmacological activities but to prove the hypothesis it need further higher studies. Keywords: