Anti-alzheimer and antioxidant activity of celastrus paniculatus seed
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Date
2011
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© 2011 Iranian Journal of Pharmaceutical Sciences
Abstract
The crude methanolic extract of the seeds ofCelastrus paniculatus along with its organic soluble fractions were tested for their possible antioxidant and antialzheirmer (AD) activity. The extracts showed prominent DPPH free radical scavenging activity, inhibiting activity of authentic peroxynitrite (ONOO-) and inhibition of total reactive oxygen species (ROS) generation. In DPPH radical scavenging assay, the EtOAc fraction showed the highest activity with a IC50 value of 25.92±1.02 mg/ml whereas aqueous fractions had no activity at all within the tested concentration. Scavenging of the authentic ONOO- system, all extract/fractions showed good activity and among them, EtOAc fraction had the highest activity with a IC50 value of 15.79±0.18 mg/ml. EtOAc fraction also showed significant (p<0.001) inhibitory activity against the total ROS generation which was almost similar with that of the positive control Trolox (IC50 16.79±0.19mg/ml). All extract/fractions exhibited statistically significant (p<0.001) cholinesterases (ChEs) inhibitory effects with IC50 values ranging between 134.7-227.5 mg/ml for AChE and 209.6-562.1 mg/ml for BChE.
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This article was published in Iranian Journal of Pharmaceutical Sciences [© 2011 Iranian Journal of Pharmaceutical Sciences] and the definite version is available at : http://en.journals.sid.ir/ViewPaper.aspx?ID=229292 The article website is at: http://en.journals.sid.ir/JournalList.aspx?ID=4452
Keywords
Anti-alzheimer, Antioxidant, Celastrus paniculatus, Cholinesterase, ROS
Citation
Alama, B., & Haque, E. (2011). Anti-alzheimer and antioxidant activity of celastrus paniculatus seed. Iranian Journal of Pharmaceutical Sciences, 7(1), 49-56