Determination of CNS Depressant and Analgesic Activity of Leaves of Artocarpus Chama.

Abstract

From different experiments, medicinal plant is using worldwide in order to dissolve drug as well as safer drug also. Methanol and pet ether extract of leaves of Artocarpus chama was assessed for CNS Depressant and Analgesic test on animal (mice) model. Administration of methanol extract and pet ether extract produced significant dose dependent CNS effect in Open field and Hole board test. Analgesic activity was evaluated by acetic acid induced pain method as well as formalin induced pain method. All the result of our experiment was statistically significant. In CNS depressant test the movement of the mice decreased in a dose depending manner comparing to the standard diazepam. Analgesic effect at writhing and formalin induced pain method comparing to control group was d\significant. The amounts of writhes decreased in acetic acid induced pain method as well as reduced licking and biting time in formalin induced licking and Biting method. Percent inhibition is 34.71% for 200 mg/kg body weight and 47.6% (p < 0.05) for 400 mg/k g body weight, whereas for Standard drug (Ibuprofen) the percent inhibition is 65.09% (p < 0.001) for 10 mg/kg body weight. In conclusion it can be said that Pet ether and Methanol extract of Artocarpus chama possesses good analgesic activity.