Synthesis and sar o acne medication

Abstract

This undergraduate research thesis explores the synthesis and structure-activity relationships (SAR) of drugs used for the treatment of acne vulgaris, which affects approximately 85% of individuals between the ages of 12 and 25. The objective of this review is to investigate the etiology of acne, current therapies, drugs used for treatment, their SAR, and synthesis. The pathophysiology of acne is multifactorial and includes increased sebum production, aberrant follicular keratinization, an increase in Propionibacterium acnes, and inflammation. The methodology used for this study involved searching for relevant articles on Google Scholar, PubMed, and Web of Science. Additionally, the study delves into the enzyme 5α-reductase, which may be the root cause of androgen production and consequently the development of acne. The review article indicates that an excess of precursor androgens, particularly in individuals with severe acne, can lead to hormonal imbalances and the development of the condition. The synthesis of newer acne medications and further research in this field will provide a better understanding of the varying degrees of effectiveness of acne medication from person to person.