In-vitro Comparative Dissolution Study of Three Different Brands (Comet, Informate, Bigmet) of Metformin Hydrochloride Tablets Available in Bangladesh

Abstract

The aim of the study was to evaluate and compare dissolution pattern of locally branded drug products of Metformin Hydrochloride in Bangladesh with each other. Glucophase® is the patent drug of Metformin Hydrochloride. Branded drugs are expensive than locally marketed drug. Substitution of dugs is very essential for the people of under developed country. Three different brands of Metformin Hydrochloride tablets in Bangladesh like Comet, Informate, Bigmet were collected from a reputed pharmacy store. Six tablets of each of the brands were used for the In Vitro dissolution study. Cumulative drug release were measured up to 50 minutes for all the brands. All the brads were compared with each other. Differential factor, f1 and similarity factor, f2 were determined. Few differences were observed during in-vitro drug release pattern of brand Comet, Informate and Bigmet with each other. f1 value of Informate with respect of comet was 6.18% and f2 value was 43.5. f1 value of Bigmet with respect of Informate was 10.6% and f2 value was 42.1. f1 value of Comet with respect of Bigmet was 7.70% and f2 value was 41.5.