Phytochemical screening and neuro modulatory activity of methanol extract of Terminalia catappa in experimental wister albino mice.

Abstract

In our daily life everyone have to deal with depression, anxiety and stress these are very similar in that time. Neurological disorder interrupt somesones daily and personal life. Main purpose of this study is to investigate the phytochemical composition and neuro-modulatory potential of the methanol extract derived from Terminalia catappa leaves. CNS depressant activity were done by hole cross, hole board and open fieild tests at 50mg/kg & 125mg/kg in body weight. It also investigates how this plant may reduce stress level by measuring both blood serum cortisol level and glucose level respectively in experimental Wistar albino mice. For antistress activity,The blood glucose level for herbal sample were respectively 2.98± 0.13 & standard groups were 1.47± 0.3419 mmol/L respectively where control group was 4.83 ± 0.450325 mmol/L. Serum cortisol level 2.78± 0.102632 & 1.83± 0.0757 ug/dl for plant extract and standard group drugs where 2.30± 0.11ug/dl for control group. A herbal sample group exhibited a significant reduction in stress, as indicated by a serum cortisol level of 1.83±0.0757 ug/ml.On the other hand, CNS depressant activity significantly reduction of frequent locomotor and exploratory activity was found in hole cross (P< 0.001) and open field test P < 0.05, P < 0.01, P < 0.001. Furthermore, both extracts also decreased the significant numbers (P < 0.001) of head dips by mice in hole-board test. Terminalia catappa, commonly known as Indian almond, has a rich history of traditional medicinal use. Phytochemical screening was conducted to identify the constituents present in the methanol extract, revealing the presence of flavonoids, alkaloids, tannins, and phenolic compounds. Subsequently, neuromodulatory assessments were carried out to explore the extract's antidepressant and anti-stress effects using behavioral paradigm