Antibiotic sensitivity pattern of bacterial isolates from Acute Lower Respiratory Tract infections in tertiary care hospital, Chattogram

Abstract

Antibiotics are frequently used for various infectious diseases e.g., acute lower respiratory tract infection (ALRTI). But, injudicious use of antibiotics often leads to antibiotic resistance which is an emerging problem. The objective of this study was taken up to analyse the antimicrobial sensitivity pattern of pathogens isolated from the sputum samples of admitted patients suffering from ALRTI in a tertiary care teaching hospital. This cross-sectional study with conducted between September 2021 to March 2022. For this study, 213 lower respiratory tract infection patients were selected by purposive sampling from Chattogram Medical College Hospital, Chattogram. Their socio-demographic information and culture-sensitivity report was recorded using a structured questionnaire. The number of male participants was higher(62%) compared to the number of female participants(32%). The majority of the participants had undergone primary education (46%) and most of the participants had an income below 20,000 BDT (67%). More than three-fourths (77%) of the participants hailed from urban areas. Streptococcus pneumoniae (43%) was the most common organism followed by Klebsiella pneumoniae (22%) and Pseudomonasaeruginosa (13%) isolated from the sputum sample.From 92 sputum samples with Streptococcus pneumoniae, 60 samples were sensitive to levofloxacin and 32 samples were resistant. From 48 sputum samples with K. pneumoniae, 36 samples were sensitive to levofloxacin and 11 samples were resistant. From 28 sputum samples with Pseudomonas aeruginosa, 26 samples were sensitive to levofloxacin and 2 samples were resistant. The commonest pathogens isolated from the sputum samples were S. pneumoniae, followed by Klebsiella and Pseudomonas. Imipenem, piperacillin/tazobactam combination and gentamicin was sensitive against Klebsiella and Pseudomonas