Determination of variation in flow property of different formulas of CMC along with Amlodipine and Propranolol

Abstract

Flow property is very important in the pharmaceutical industry for the manufacturing process such as blending, tablet compression, capsule filling, transportation, and in scale-up operation. The purpose of this research work was to find out that ratio of pharmaceutical excipients in a mixture that will provide maximum or minimum flow property. The equations that i proposed will be helpful for determining the flow property of new solid drug formulations. I had measured several parameters, such as, bulk volume, tapped volume, Carr’s index, Hausner ratio and angle of repose for different mixture of same pharmaceutical excipients. We had done this for different mixtures of different excipients with different ratios of CMC to determine different equations. I evaluated the laboratory experimental data to determine several specific equations (y= mx + c) for particular mixtures of specific pharmaceutical excipients. After doing the research I found that at the lowest amount of CMC I used in set 1 (3%:97%) with amlodipine gave best result and at the ratio (30%:70%) gave very poor result with amlodipine. For propranolol I got the best result when CMC was lower at the ratio (3%:97%) and got poor result when CMC was higher at the ratio (30%:70%). For a new solid drug formulations flow property of pharmaceutical excipients can be predicted and measured by these equations.