CRISPR: a revolutionary tool for modeling and treating cancer and Duchenne muscular dystrophy

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dc.contributor.advisorRahman, Kazi Fatema
dc.contributor.authorEva, Israt Ara Jannat
dc.date.accessioned2023-01-18T09:50:46Z
dc.date.available2023-01-18T09:50:46Z
dc.date.issued2022-04
dc.descriptionCataloged from PDF version of thesis.
dc.descriptionIncludes bibliographical references (pages 36-49).
dc.descriptionThis thesis is submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy, 2022.
dc.description.abstractThe novel CRISPR/Cas system is an effective and widely used gene-editing tool that has created the opportunity to study gene function and understand the pathogenic mechanisms underlying various genetic disorders. It has uncovered the pathophysiology of several previously unsolved medical conditions and is currently an essential genome-editing tool being employed to develop new drugs and innovative gene therapies for potentially life-threatening diseases such as, cancer and Duchenne muscular dystrophy (DMD). The specificity, accuracy, high probability of successful outcomes, cost and time effectiveness of CRISPR/Cas systems have made it a reliable means to treat cancer and DMD over other previously used genetic modification tools. This review will discuss how CRISPR/Cas can be utilized to design in vivo and in vitro disease models, target cancer cells, and aid in the identification of novel drug targets to treat cancer and DMD patients.
dc.identifier.otherID 18146047
dc.identifier.otherhttps://dspace.bracu.ac.bd/server/api/core/items/c3eaaeb0-6f56-4d12-a4bd-581784e16067
dc.identifier.urihttp://hdl.handle.net/10361/17764
dc.language.isoen
dc.publisherBRAC University
dc.sourceBRAC University Institutional Repository
dc.subjectCRISPR/Cas9 mechanism
dc.subjectIn vivo and in vitro modeling
dc.subjectCRISPR/Cas9 delivery
dc.subjectMutation targeting in cancer and DMD
dc.subjectChromosomal rearrangement
dc.subjectMouse modeling
dc.subjectOff-target limitation
dc.subjectDMD mutation in human iPSCs
dc.subjectMyoediting of DMD
dc.subjectTherapeutic application of CRISPR
dc.titleCRISPR: a revolutionary tool for modeling and treating cancer and Duchenne muscular dystrophy
dc.typeThesis

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