Determination of Variation in Flow property of Different sets of PVP along with Amlodipine and propranolol

Abstract

Flow property is very important in the pharmaceutical industry for the manufacturing process such as blending, tablet compression, capsule filling, transportation, and in scale-up operation. The purpose of this research work was to find out the ratio of pharmaceutical excipients in a mixture that will provide different types of desired flow property. We measured several parameters, such as, bulk volume, tapped volume, Carr’s index, Hausner’s ratio and angle of repose for different mixture of same pharmaceutical excipients. We did this for different ratios of PVP to determine different equations. We evaluated the laboratory experimental data to determine several specific equations (y= mx + c) for particular mixtures of specific pharmaceutical excipients. For a new solid drug formulations flow property of pharmaceutical excipients can be predicted and measured by these equations.