Determination of Flow Property of Different Groups of Excipients with Different Amounts of Disintegrants

Abstract

Powder flow characteristic is an important parameter during drug manufacturing process. The aim of this research work is determine the power flow characteristics of different excipients. Powder flow characteristic was determined using different parameter, for example, angle of repose, Carr’s index and Hausner ratio. At first, some excipients were selected to form a mixture and then three disintegrants, eg., starch, polyvinyl pyrrolidone, carboxymethyl cellulose and microcrystalline cellulose were added in different ratios. Finally values of angle of repose, Carr’s index and Hausner ratio of different ratios were determined. Variation in the values of angle of repose, Carr’s index and Hausner ratio were observed after addition of different amounts of disintegrants. It was observed that flow property was improved after addition of some excipients. This research work for the thesis project has shown the improvement in flow characteristic while using different amounts of disintegrants in a drug formulation. In addition the numerical data, the regression values and equations may further be used to predict the flow characteristics of these widely used excipients, and this will be beneficial for manufacturing new products or transforming the existing one in pharmaceutical industry.