An Isolation, Characterization and In-vitro Evaluation Study of Cholinesterase Inhibitory and Antioxidant Activities of Mimosa pudica for the Treatment ofNeurodegenerative Disorders

Abstract

Among the pathologic hypotheses of Alzheimer’s disease (AD), cholinergic deficit and oxidative stress have been implicated as two major hallmarks. Therefore, inhibition of cholinesterase and oxidation are the two promising strategies in the development of a drug for AD. Mimusa pudica plant extract is used in this research to investigate its anticholinesterase and antioxidant potentials. Anticholinesterase activity was measured by modified Ellman’s method. Antioxidant potentials were evaluated by the assay of reducing power, radical scavenging. The Methanolic extract showed strong antioxidant effect. Additionally, the extract exhibited pronounced reducing capacity. The plant extract found moderate inhibitor of cholinesterase (Both Acetylcholinesterase and Butyrylcholinesterase). The tested sample reflects potential antioxidative and moderate anticholin-esterase inhibitory effect which may warrant its effectiveness in the treatment of AD.