Formulation and evaluation of quality parameters of metronidazole 200mg and 400mg tablet

Abstract

Metronidazole is a common antibiotic that is used to treat a wide variety of infections. It works by stopping the growth of certain bacteria and parasites. The aim of this study is to prepare a formula of metronidazole 200mg/ 400mg tablet and evaluate quality parameters of this products according to the United States Pharmacopoeia (USP) and the British Pharmacopoeia (BP) methods. Although the commercial price of this tablet is low, however, as the product is widely prescribed and consumed by huge number of poor patients, this study may find a more economical formulation that can obviously make an impression to patients. In this study the quality control parameters of formulated tablets were evaluated by doing weight variation test, hardness test, thickness, friability test, potency and dissolution by UV-spectroscopy following BP/USP criteria. The assay result and dissolution rate studies showed quite similar with other brand’s tablet of metronidazole. By considering the result of the quality parameters the quality and efficacy of the newly formulated tablets were ensured and it may be marketed comparing metronidazole tablet.