A review on the pathophysiology and potential drugs for Covid-19

Abstract

The ongoing 2019 coronavirus pandemic caused by SARS-CoV-2 has generated enormous obstacles to the healthcare system worldwide. There seem to be no specific therapeutic agent against the virus currently. Infection preventive and mitigation strategies and supportive treatments are the main area of concern for modern health management. A prospective list of repurposed medicines with suitable pharmacological effects and therapeutic effectiveness in the treatment of COVID-19 patients has been suggested by emerging scientific and clinical evidence about virologic SARS-CoV-2. These medications and therapeutic agents include antiviral agents (remdesivir, hydroxychloroquine, chloroquine, lopinavir, favipiravir, oseltamivir, ivermectin) and supportive agents such as; antibiotics, ascorbic acid, corticosteroids, nitric oxide, IL-6 antagonists), biological products, vaccines and many more combinations of therapy.